{"id":"W1989940296","doi":"10.1038/ncb2581","title":"Dll1+ secretory progenitor cells revert to stem cells upon crypt damage","year":2012,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":789,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Cancer Institute","keywords":"Cell biology; Stem cell; Biology; Notch signaling pathway; Progenitor cell; Crypt; LGR5; Gene silencing; Cancer stem cell; Gene; Genetics; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000264502,0.0004288604,0.0007102776,0.0006244685,0.000339582,0.001120938,0.0004895047,0.0008666439,0.004531651],"category_scores_gemma":[0.0002437334,0.0003738482,0.0005472354,0.0003261847,0.0006153161,0.0004873331,0.0006556848,0.003267984,0.002055205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000560869,"about_ca_system_score_gemma":0.0003817813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001096494,"about_ca_topic_score_gemma":0.001224213,"domain_scores_codex":[0.9994469,0.00004373528,0.00007438996,0.0001061153,0.0001759146,0.0001529571],"domain_scores_gemma":[0.9992587,0.0001434697,0.0001584351,0.0001221474,0.00005813756,0.0002591286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002079843,0.00008481907,0.0004030249,0.00003987814,0.00001291087,0.0003105628,0.00006822837,0.0001774956,0.9953051,0.0006118108,0.0002631157,0.002515186],"study_design_scores_gemma":[0.00003915663,0.0002269881,0.002866869,0.000005838464,0.00001557478,0.0006255591,0.000135025,0.001079322,0.9892425,0.0001999777,0.00555527,0.000007976194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848631,0.0009570152,0.005415448,0.0006065568,0.0001789312,0.00009713247,0.002624167,0.0007764468,0.004481118],"genre_scores_gemma":[0.9828064,0.0003105027,0.00187887,0.0002857159,0.00001954095,0.0000610817,0.001925643,0.000227006,0.01248509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004531651,"threshold_uncertainty_score":0.0151599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01274162064966461,"score_gpt":0.2789846285252335,"score_spread":0.2662430078755689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}