{"id":"W1989949054","doi":"10.1007/s13238-014-0031-6","title":"Driver mutations of cancer epigenomes","year":2014,"lang":"en","type":"article","venue":"Protein & Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":197,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Howard Hughes Medical Institute; National Institute of General Medical Sciences; U.S. Department of Defense","keywords":"Epigenetics; Epigenome; Biology; Cancer; Carcinogenesis; Cancer epigenetics; Epigenetic therapy; DNA methylation; EZH2; Cancer research; Chromatin; Genetics; Epigenomics; Histone; Bioinformatics; Histone methyltransferase; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009759783,0.00006382369,0.00006917243,0.00002153594,0.00003269512,0.00000538639,0.00007596536,0.00005997659,0.00005075046],"category_scores_gemma":[0.00002450647,0.00006139607,0.00004192784,0.00004245702,0.00003665249,0.000001165442,0.00003033521,0.00002880827,0.000008834826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004159247,"about_ca_system_score_gemma":0.00002899284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006943483,"about_ca_topic_score_gemma":0.00004024999,"domain_scores_codex":[0.9995355,0.00003556106,0.0001202814,0.0001422598,0.00006822287,0.00009815729],"domain_scores_gemma":[0.9996472,0.000005457148,0.00007421418,0.0001670821,0.00007264221,0.0000333837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005633514,0.00002555648,0.004803107,0.00002178013,0.000007608747,6.109357e-8,0.00003805032,0.0002620616,0.9889122,0.00009495861,0.00002150882,0.005807491],"study_design_scores_gemma":[0.000176925,0.00009272276,0.004058619,0.000005341256,0.000008535002,3.187009e-8,0.000008591605,0.00008121321,0.9572957,0.0006159897,0.03758068,0.00007566028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985657,0.002566112,0.007113984,0.00005750756,0.00005974733,0.0001829576,0.000008731667,0.000004410781,0.004349543],"genre_scores_gemma":[0.9957039,0.0001502118,0.002317288,0.00002049938,0.0001358171,0.00004373167,0.00003366937,0.00001116256,0.001583757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03755918,"threshold_uncertainty_score":0.2503659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006645999395679019,"score_gpt":0.2479097196690711,"score_spread":0.241263720273392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}