{"id":"W1989966460","doi":"10.1158/1535-7163.mct-07-0515","title":"UBE1L represses PML/RARα by targeting the PML domain for ISG15ylation","year":2008,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"Cleveland Clinic Foundation; National Institutes of Health; Cleveland Clinic; National Cancer Institute; Samuel Waxman Cancer Research Foundation","keywords":"Promyelocytic leukemia protein; Acute promyelocytic leukemia; Ubiquitin; Biology; Retinoic acid; Cancer research; ISG15; Psychological repression; HEK 293 cells; Tretinoin; Cell biology; Gene expression; Receptor; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002152855,0.0002373263,0.0001638145,0.00002039751,0.0003598171,0.00003810915,0.000372737,0.0001985852,0.00002001009],"category_scores_gemma":[0.00003818051,0.0001873749,0.0001588338,0.0001265281,0.0001882895,0.000006787558,0.00006605066,0.0001336841,0.000003140375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003547537,"about_ca_system_score_gemma":0.000168044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002067671,"about_ca_topic_score_gemma":0.000003572064,"domain_scores_codex":[0.9986072,0.00009447827,0.0002695112,0.0004461449,0.0002263159,0.0003563559],"domain_scores_gemma":[0.9991259,0.00002864951,0.0001507482,0.0004693292,0.000173094,0.00005230608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009351806,0.00003657302,0.0007768598,0.0000360413,0.0001501549,0.000004051986,0.0002130956,0.0003397768,0.9874811,0.0001230791,0.008201684,0.002544081],"study_design_scores_gemma":[0.0004250485,0.00009055434,0.00003102131,0.000008402594,0.00004143782,0.00001114664,0.00007693315,0.0001276826,0.6636491,0.0004622619,0.3348729,0.0002035906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8153543,0.05438365,0.1270196,0.001176516,0.0003304335,0.0006013516,0.00006294654,0.00004095069,0.001030307],"genre_scores_gemma":[0.9891221,0.003724183,0.00203382,0.002898823,0.0003704748,0.0002780019,0.0002491913,0.00007569232,0.001247709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3266712,"threshold_uncertainty_score":0.7640925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01615491777438762,"score_gpt":0.2706241779061656,"score_spread":0.254469260131778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}