{"id":"W1989993156","doi":"10.1016/j.str.2005.08.001","title":"IRF-3 Releases Its Inhibitions","year":2005,"lang":"en","type":"letter","venue":"Structure","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Coactivator; Interferon regulatory factors; IRF1; Interferon; Cell biology; Mechanism (biology); Biology; Chemistry; Computational biology; Transcription factor; Genetics; Gene; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.00002966961,0.0004185144,0.000439475,0.0002208651,0.0002165748,0.00003181224,0.0003639512,0.002203264,0.02194676],"category_scores_gemma":[0.00009815182,0.0003481689,0.0002276886,0.00009808749,0.0001907396,0.00007346254,0.0001018981,0.003142242,0.002910907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000702958,"about_ca_system_score_gemma":0.0001248188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001932553,"about_ca_topic_score_gemma":0.00001657388,"domain_scores_codex":[0.9984282,0.0002512213,0.0003153832,0.0004192051,0.00004926007,0.0005367557],"domain_scores_gemma":[0.9991426,0.0001161224,0.0001535835,0.0004751612,0.00009999949,0.00001249812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005461462,0.000007659554,0.000002212236,0.00003988072,0.0001609761,0.00005489389,0.00007745453,4.222877e-7,0.0642117,0.00009304612,0.9339247,0.001372398],"study_design_scores_gemma":[0.0003804298,0.00008776198,0.00006809446,0.00009659852,0.00007460511,0.0005319769,0.0000217472,1.158607e-7,0.07802713,0.0001053222,0.9202539,0.0003523119],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0211684,0.03937935,0.00001008147,0.9070801,0.007853957,0.0008099528,0.004909559,0.0005506079,0.01823797],"genre_scores_gemma":[0.0745868,0.0002625776,0.00004414768,0.6994889,0.003140556,0.00002495138,0.006244722,0.0001064193,0.216101],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2075913,"threshold_uncertainty_score":0.999897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016570751539296,"score_gpt":0.2311284087193239,"score_spread":0.220962701203931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}