{"id":"W1990013773","doi":"10.1021/ol010231q","title":"Hybridization Properties of Aromatic Peptide Nucleic Acids:  A Novel Class of Oligonucleotide Analogues","year":2001,"lang":"en","type":"article","venue":"Organic Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Boehringer Ingelheim (Canada)","funders":"","keywords":"Oligonucleotide; Chemistry; Nucleic acid; DNA; RNA; Peptide nucleic acid; Intramolecular force; Duplex (building); Nucleic acid thermodynamics; Peptide; Nucleic acid structure; Stereochemistry; Biochemistry; Combinatorial chemistry; Molecular biology; Computational biology; Gene; Base sequence; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002585188,0.0002728257,0.0002686234,0.0001282206,0.0001949287,0.0002876927,0.000300848,0.0004448553,0.001762686],"category_scores_gemma":[0.0005145979,0.0001225321,0.0001156217,0.0001882117,0.0001839364,0.0002368169,0.0001798437,0.0003457255,0.0004250398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002020291,"about_ca_system_score_gemma":0.00009594684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002191654,"about_ca_topic_score_gemma":0.000189072,"domain_scores_codex":[0.9997532,0.00007345882,0.00001341407,0.00006841242,0.00005451157,0.00003701511],"domain_scores_gemma":[0.9996994,0.0001089591,0.00005370595,0.00002331487,0.00004703995,0.00006753036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009202552,0.00001502854,0.00007395932,0.0000495987,0.000003125576,0.00005626732,0.0000272996,0.0001302138,0.9973524,0.0001708392,0.00002976043,0.00199959],"study_design_scores_gemma":[0.00001535849,0.0007874818,0.001048201,0.000006408615,0.0000191542,0.0006571969,0.00002012196,0.00068329,0.990831,0.00007147558,0.005848088,0.00001219654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788452,0.004025033,0.0104783,0.00009788973,0.00004569075,0.00006574814,0.0001642794,0.0001230308,0.006154784],"genre_scores_gemma":[0.9853866,0.001100939,0.009822433,0.0001135807,0.00003045928,0.0000538647,0.0002211361,0.00002928283,0.003241736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001762686,"threshold_uncertainty_score":0.005896807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00914690553044884,"score_gpt":0.1948939277418364,"score_spread":0.1857470222113876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}