{"id":"W1990020715","doi":"10.1038/leu.2008.84","title":"Dasatinib induces durable cytogenetic responses in patients with chronic myelogenous leukemia in chronic phase with resistance or intolerance to imatinib","year":2008,"lang":"en","type":"article","venue":"Leukemia","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":354,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Dasatinib; Medicine; Imatinib; Chronic myelogenous leukemia; Internal medicine; Gastroenterology; Neutropenia; Imatinib mesylate; Leukemia; Oncology; Chemotherapy; Myeloid leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002921411,0.0002043477,0.0008105345,0.0001690588,0.000204223,0.0003313317,0.000166188,0.0002366098,0.002086886],"category_scores_gemma":[0.0006373334,0.0001183775,0.0003174555,0.0003199757,0.0002371638,0.0002431195,0.0001802955,0.0005989074,0.0003794777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002969344,"about_ca_system_score_gemma":0.000331484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003410404,"about_ca_topic_score_gemma":0.001253,"domain_scores_codex":[0.9998629,0.00003539408,0.00001421926,0.00001839004,0.00001755931,0.00005156462],"domain_scores_gemma":[0.999768,0.00006711163,0.00004992862,0.00003382759,0.00001477665,0.00006640672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1041774,0.006034006,0.09029489,0.0007144499,0.001443409,0.00359014,0.0005549049,0.003900861,0.2952724,0.001042487,0.01095788,0.4820172],"study_design_scores_gemma":[0.07859839,0.1626171,0.5416006,0.00008564237,0.001503164,0.024556,0.0007915471,0.006780681,0.1342681,0.001899372,0.04718263,0.0001166916],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963736,0.001262915,0.0002032412,0.0002933804,0.00003840321,0.00005011672,0.0002098862,0.00003969408,0.001528782],"genre_scores_gemma":[0.998904,0.000264574,0.000114342,0.00007576681,0.0000180156,0.00001532037,0.0003141499,0.000004799468,0.0002891753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002086886,"threshold_uncertainty_score":0.006981313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02218488206773787,"score_gpt":0.2795651517636827,"score_spread":0.2573802696959449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}