{"id":"W1990047266","doi":"10.1002/gcc.20538","title":"Hydrocortisone down‐regulates the tumor suppressor gene <i>BRCA1</i> in mammary cells: A possible molecular link between stress and breast cancer","year":2008,"lang":"en","type":"article","venue":"Genes Chromosomes and Cancer","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Hydrocortisone; Carcinogenesis; Hormone; Breast cancer; Biology; Endocrinology; Cancer research; Internal medicine; Estrogen; Transcription factor; Mammary tumor; Downregulation and upregulation; Gene expression; Cell culture; Cancer; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002894807,0.000319956,0.0003858553,0.00009082383,0.0003194409,0.000114924,0.0003644429,0.00009290438,0.0001014286],"category_scores_gemma":[0.000008694461,0.0002339468,0.00007540909,0.0003669802,0.0003483242,0.000214028,0.0002759923,0.0001967076,0.000002920724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004581983,"about_ca_system_score_gemma":0.0001507336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001267116,"about_ca_topic_score_gemma":0.0001710635,"domain_scores_codex":[0.9979676,0.0001163975,0.0003301201,0.0007069865,0.0003225367,0.0005563357],"domain_scores_gemma":[0.9991407,0.0001177632,0.0001393679,0.0003947306,0.00003364751,0.000173798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001509141,0.00004925249,0.07621069,0.0001258245,0.00004227624,0.0004092184,0.0005531139,0.0005225886,0.8126673,0.00003733829,0.0001545036,0.109077],"study_design_scores_gemma":[0.0009051365,0.00006826795,0.1437165,0.0001321729,0.00004010263,0.0002690833,0.00004711633,0.0007961657,0.851398,0.00008086135,0.002169729,0.0003769021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9537641,0.04324277,0.0000144767,0.001671046,0.0001546367,0.0003845023,0.0006697782,0.0000448181,0.00005392105],"genre_scores_gemma":[0.9277012,0.07055688,0.00003515555,0.000712353,0.0003266187,0.0002987022,0.000004501205,0.00003785794,0.0003267471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1087001,"threshold_uncertainty_score":0.9540076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01493153346290854,"score_gpt":0.2443816826956031,"score_spread":0.2294501492326945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}