{"id":"W1990070722","doi":"10.1021/bi700359e","title":"Recruitment of Both Uniform and Differential Binding Energy in Enzymatic Catalysis:  Xylanases from Families 10 and 11","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biofuel production and bioconversion","field":"Engineering","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Enzyme; Binding energy; Differential (mechanical device); Catalysis; Chemistry; Biochemistry; Enzyme catalysis; Biophysics; Biology; Physics; Thermodynamics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004759723,0.0000862014,0.0001087898,0.00005584118,0.00001573093,0.000008629443,0.00003584366,0.00007743965,0.00003535128],"category_scores_gemma":[0.000006031803,0.00007981225,0.00001565324,0.00006857525,0.00004168893,0.00002652332,0.0000266807,0.00003681968,5.913589e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002820374,"about_ca_system_score_gemma":0.000004566529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002559892,"about_ca_topic_score_gemma":0.00004672378,"domain_scores_codex":[0.9995704,0.000003018725,0.0001449784,0.0001226406,0.00006261666,0.00009628856],"domain_scores_gemma":[0.9998155,0.00001642036,0.00002504021,0.00009557094,0.000006299289,0.00004114547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001578103,0.00002504964,0.003979527,0.0002885247,0.00002774225,0.000002361295,0.0001251477,0.000002263236,0.9900675,0.000007625407,0.0001610424,0.005297376],"study_design_scores_gemma":[0.0002594688,0.000007909286,0.003380642,0.00005108196,0.00001552807,0.000001957645,0.0005754587,0.0003975192,0.994432,0.000009629906,0.0007739119,0.00009483634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983448,0.001187663,0.00005992615,0.00001128476,0.00005720054,0.0000340453,0.00001448998,0.00002767748,0.0002629217],"genre_scores_gemma":[0.9992033,0.0004024121,0.0001291677,0.000004082435,0.00004689321,0.000002501371,0.00006509202,0.000006044673,0.0001404711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00520254,"threshold_uncertainty_score":0.3254649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01436687381184188,"score_gpt":0.2125002158053758,"score_spread":0.1981333419935339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}