{"id":"W1990076574","doi":"10.1126/science.1208592","title":"An Expanded Palette of Genetically Encoded Ca <sup>2+</sup> Indicators","year":2011,"lang":"en","type":"article","venue":"Science","topic":"Advanced Fluorescence Microscopy Techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1328,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Palette (painting); Computational biology; Biology; Genetics; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005293135,0.0007477938,0.0005479909,0.0008274553,0.0004154841,0.0009193097,0.0008469458,0.0006606838,0.00651946],"category_scores_gemma":[0.0004756826,0.0005052759,0.0005793085,0.0004923987,0.0005196763,0.001143399,0.001116887,0.001775346,0.002134585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000337654,"about_ca_system_score_gemma":0.0002515163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002183426,"about_ca_topic_score_gemma":0.0003750404,"domain_scores_codex":[0.9997483,0.00002658991,0.0000164401,0.0000592269,0.0001170167,0.0000324222],"domain_scores_gemma":[0.9995819,0.00009474207,0.00004043727,0.00008488324,0.00009271132,0.000105427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002210339,0.00002938211,0.0002013297,0.0001114099,0.00001385093,0.0001597119,0.00004468459,0.0004489993,0.9693875,0.001511071,0.002028842,0.02584228],"study_design_scores_gemma":[0.00004488842,0.0002989251,0.001421804,0.00005574373,0.00006110981,0.001844851,0.00003578154,0.003071126,0.9149103,0.001526281,0.07667033,0.00005885107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5469649,0.01541516,0.3461238,0.004308917,0.001238577,0.0003375103,0.004890017,0.01753563,0.06318551],"genre_scores_gemma":[0.5399312,0.0113614,0.3949139,0.002362689,0.0003288526,0.0005549322,0.005537686,0.002901136,0.04210816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00651946,"threshold_uncertainty_score":0.02180982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01064318915530466,"score_gpt":0.2809713600093288,"score_spread":0.2703281708540241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}