{"id":"W1990089954","doi":"10.1038/ni.1676","title":"Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK","year":2008,"lang":"en","type":"article","venue":"Nature Immunology","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":598,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; University Health Network; Children's Hospital of Eastern Ontario","funders":"National Institute of General Medical Sciences; Howard Hughes Medical Institute","keywords":"TRAF2; Cell biology; Proteasome; Ubiquitin; Kinase; Biology; Cancer research; Gene; Immunology; Genetics; Tumor necrosis factor alpha","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005217581,0.0005649038,0.0004453871,0.0002989743,0.0004356638,0.001390341,0.0004302959,0.0002743605,0.001798769],"category_scores_gemma":[0.0004357107,0.0004331597,0.0003937886,0.00020855,0.0004000022,0.0007915926,0.0009667363,0.0009374106,0.001207797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001252425,"about_ca_system_score_gemma":0.0006486669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000520781,"about_ca_topic_score_gemma":0.0009486552,"domain_scores_codex":[0.9994969,0.0000360899,0.00002477415,0.000139543,0.0001498961,0.0001527094],"domain_scores_gemma":[0.999598,0.00002906832,0.0001003675,0.00006903322,0.00008651581,0.0001170865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002013805,0.00001976007,0.0005206846,0.00005609922,0.00001095158,0.0001667471,0.00002792349,0.0001142351,0.9946061,0.001105871,0.0002701732,0.002900123],"study_design_scores_gemma":[0.00007071431,0.0001111599,0.0246396,0.00002175753,0.00003251541,0.001591189,0.0001700474,0.002912632,0.9536511,0.001950742,0.01482058,0.00002786636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9391234,0.01334908,0.03220095,0.0008115611,0.0005322601,0.00006553698,0.0006041268,0.001172846,0.01214031],"genre_scores_gemma":[0.9870757,0.001371116,0.005188995,0.00008787692,0.0000643258,0.00004569071,0.0006089759,0.0001072978,0.005449967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001798769,"threshold_uncertainty_score":0.009087026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01026903648338651,"score_gpt":0.2289785743961575,"score_spread":0.218709537912771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}