{"id":"W1990144440","doi":"10.1016/j.stem.2009.03.001","title":"Histone Deacetylase Inhibition Elicits an Evolutionarily Conserved Self-Renewal Program in Embryonic Stem Cells","year":2009,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":169,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; University of Washington","keywords":"Biology; Sodium butyrate; Embryonic stem cell; Cell biology; Stem cell; Butyrate; Histone deacetylase; Histone; Histone deacetylase inhibitor; Cellular differentiation; Genetics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001760814,0.0002922495,0.0002958448,0.0003012177,0.0001474995,0.000318769,0.0002458205,0.0002460683,0.0007549033],"category_scores_gemma":[0.0001400557,0.0001669005,0.0002752521,0.0001736486,0.0001722613,0.0001267311,0.0002645005,0.0005499353,0.0002055497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003493643,"about_ca_system_score_gemma":0.0002038343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003898412,"about_ca_topic_score_gemma":0.0009973766,"domain_scores_codex":[0.9998498,0.0000170835,0.00001775302,0.00002525784,0.00005184946,0.00003822082],"domain_scores_gemma":[0.999846,0.00003312288,0.00004662552,0.00002743931,0.00001248687,0.00003428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005941088,0.00001664241,0.0001625889,0.000007905888,0.000004239954,0.00003068196,0.000003053138,0.00004540972,0.9987918,0.00007747568,0.00001752634,0.0007833424],"study_design_scores_gemma":[0.00001800545,0.0001620483,0.007113753,0.000002413112,0.00001762328,0.0002316813,0.00001127321,0.0007796609,0.990624,0.00004790161,0.0009881748,0.000003467771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948808,0.00115574,0.001642833,0.00008737425,0.00003388438,0.00002162584,0.0002678437,0.00009339677,0.001816477],"genre_scores_gemma":[0.9961457,0.0005174655,0.0008224862,0.00006155157,0.00001046345,0.00001731665,0.0004744556,0.00003134224,0.001919095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007549033,"threshold_uncertainty_score":0.002534807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01265595278791736,"score_gpt":0.2617821419859809,"score_spread":0.2491261891980636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}