{"id":"W1990218988","doi":"10.1074/jbc.r700013200","title":"Innate Immunity Minireview Series: Making Biochemical Sense of Nucleic Acid Sensors That Trigger Antiviral Innate Immunity","year":2007,"lang":"en","type":"review","venue":"Journal of Biological Chemistry","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"TRIF; Interferon regulatory factors; Interferon; Biology; Innate immune system; TLR7; RIG-I; Toll-like receptor; IRF3; MDA5; TLR3; Cell biology; Pattern recognition receptor; Receptor; Virology; RNA; RNA interference; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005544871,0.001251874,0.00106583,0.001214511,0.000492343,0.001707744,0.001362936,0.001495902,0.03406281],"category_scores_gemma":[0.0009780639,0.0003769455,0.0006090649,0.0008031046,0.0004221343,0.002126827,0.001008814,0.002775957,0.02013955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008278842,"about_ca_system_score_gemma":0.0009542634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003678788,"about_ca_topic_score_gemma":0.0009698318,"domain_scores_codex":[0.9995254,0.00005597564,0.0000420465,0.00009787168,0.0002097555,0.00006890928],"domain_scores_gemma":[0.999191,0.0001253482,0.00006912868,0.00003312955,0.0003546898,0.0002267911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009835734,0.00006828456,0.0001193217,0.002927125,0.0000507502,0.0001129194,0.00006113265,0.00009364205,0.005551993,0.001268756,0.8841182,0.1055295],"study_design_scores_gemma":[0.000006498524,0.00003963796,0.0002114421,0.0002193266,0.00002129801,0.0002111427,0.00002371175,0.00002094373,0.0008382024,0.0003118404,0.9980888,0.000007278557],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001451603,0.6239734,0.0009960686,0.01308319,0.324361,0.0001096249,0.0005403023,0.000302902,0.03518189],"genre_scores_gemma":[0.006611357,0.5803368,0.001100462,0.01307345,0.2938808,0.0001269833,0.001398537,0.0001865173,0.1032851],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.03406281,"threshold_uncertainty_score":0.1139514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07890291546020997,"score_gpt":0.3389919627229336,"score_spread":0.2600890472627236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}