{"id":"W1990226486","doi":"10.1038/nature12051","title":"High-level semi-synthetic production of the potent antimalarial artemisinin","year":2013,"lang":"en","type":"article","venue":"Nature","topic":"Malaria Research and Control","field":"Medicine","cited_by":2068,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saskatchewan Research Council (Canada)","funders":"Sanofi; Bill and Melinda Gates Foundation","keywords":"Artemisinin; Artemisia annua; Plasmodium falciparum; Chemistry; Sesquiterpene; Sesquiterpene lactone; Malaria; Artesunate; Synthetic biology; Biology; Biochemistry; Combinatorial chemistry; Stereochemistry; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000249465,0.0004269508,0.0003190928,0.0001920952,0.0001597062,0.0005054495,0.0003465543,0.0002992435,0.00136934],"category_scores_gemma":[0.0002489426,0.000136106,0.0003407737,0.0002268389,0.0002317098,0.0002731005,0.0004385865,0.0007222243,0.0008850212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003209393,"about_ca_system_score_gemma":0.00023461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002709388,"about_ca_topic_score_gemma":0.0004379304,"domain_scores_codex":[0.9998245,0.00004416586,0.00001418907,0.0000276313,0.00006513971,0.00002443902],"domain_scores_gemma":[0.9998757,0.00002668356,0.00002628663,0.00002641439,0.00001992357,0.00002493986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007909034,0.00003480358,0.0000798259,0.0000523991,0.000006860386,0.00004852748,0.00001260476,0.0002463329,0.9952912,0.000541431,0.000186039,0.003420778],"study_design_scores_gemma":[0.00001342904,0.0002016115,0.0003731321,0.000004580727,0.00001274344,0.0001617771,0.00001276116,0.001114976,0.99223,0.0002195867,0.005648708,0.000006600311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8762903,0.004902457,0.09732678,0.0006575054,0.0005449687,0.000219976,0.003823441,0.0007973232,0.01543731],"genre_scores_gemma":[0.9734226,0.001220462,0.01898157,0.00004724266,0.00002958833,0.00003234322,0.002421735,0.00005955794,0.003784835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00136934,"threshold_uncertainty_score":0.004580855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01052131641053166,"score_gpt":0.2505948287664932,"score_spread":0.2400735123559616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}