{"id":"W1990236719","doi":"10.1158/0008-5472.can-05-2516","title":"Melanosomal Targeting Sequences from gp100 Are Essential for MHC Class II–Restricted Endogenous Epitope Presentation and Mobilization to Endosomal Compartments","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hôpital Notre-Dame","funders":"","keywords":"MHC class I; MHC class II; Endosome; Biology; CD74; CD8; MHC restriction; Epitope; Antigen presentation; Major histocompatibility complex; Antigen; Cell biology; Cross-presentation; Antigen processing; T cell; Immunology; Immune system; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007053796,0.0003418061,0.0001722034,0.0001144308,0.0001288687,0.0002215505,0.000132268,0.0002942603,0.001056107],"category_scores_gemma":[0.0001321227,0.0001585648,0.000257269,0.0001140749,0.0001694849,0.0001588369,0.000214643,0.0005509266,0.0006201222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003185421,"about_ca_system_score_gemma":0.000217883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007330826,"about_ca_topic_score_gemma":0.0009266593,"domain_scores_codex":[0.9999226,0.00001249231,0.000008651754,0.00001368719,0.00002488876,0.00001761753],"domain_scores_gemma":[0.9998847,0.00002419698,0.00003533424,0.00001733102,0.00001068765,0.00002768517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000202929,0.000004807829,0.00004317483,0.00001190474,0.000001545839,0.00002949042,0.000004259114,0.0000223376,0.9995177,0.00003320694,0.00000772358,0.0003036044],"study_design_scores_gemma":[0.00001134708,0.00008095591,0.005334372,0.000007449318,0.00001248956,0.0003837547,0.00001818073,0.0006166459,0.9901906,0.00005561335,0.00328475,0.000003763559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928519,0.0005108592,0.005352819,0.00006582155,0.00001394441,0.00002969442,0.000359614,0.00005186525,0.0007635787],"genre_scores_gemma":[0.9919013,0.0003903329,0.004095168,0.0000481527,0.000006100593,0.00003966063,0.001436046,0.0000431005,0.002040009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001056107,"threshold_uncertainty_score":0.003533006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0560335684438591,"score_gpt":0.3495175945289421,"score_spread":0.293484026085083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}