{"id":"W1990236719","doi":"10.1158/0008-5472.can-05-2516","title":"Melanosomal Targeting Sequences from gp100 Are Essential for MHC Class II–Restricted Endogenous Epitope Presentation and Mobilization to Endosomal Compartments","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hôpital Notre-Dame","funders":"","keywords":"MHC class I; MHC class II; Endosome; Biology; CD74; CD8; MHC restriction; Epitope; Antigen presentation; Major histocompatibility complex; Antigen; Cell biology; Cross-presentation; Antigen processing; T cell; Immunology; Immune system; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026244,0.0001730165,0.000264153,0.0002131539,0.0009420415,0.0000748789,0.0003128369,0.00017682,0.0003203513],"category_scores_gemma":[0.0002070531,0.0001614501,0.00005482001,0.0003055478,0.0002423065,0.0001675875,0.0001738059,0.0002438436,0.00003582879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001332846,"about_ca_system_score_gemma":0.0001710931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005838474,"about_ca_topic_score_gemma":0.0003149681,"domain_scores_codex":[0.9979336,0.0005838365,0.0003334249,0.0004375156,0.0001164386,0.0005951439],"domain_scores_gemma":[0.9987609,0.0005499002,0.0001094522,0.0002494487,0.000299229,0.00003101794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001934537,0.0001311903,0.006585307,0.00002216087,0.0001229196,0.000004906205,0.0005621549,0.0001569586,0.9837735,0.0001682104,0.004663009,0.001875105],"study_design_scores_gemma":[0.002397373,0.0004421799,0.01727997,0.00006365961,0.00002332621,0.000007469783,0.0005645929,0.00003446402,0.9493663,0.0004250754,0.02920245,0.000193096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807913,0.01615897,0.0001958795,0.0006066348,0.000582926,0.001212154,0.0003144495,0.00004690457,0.00009076439],"genre_scores_gemma":[0.9963946,0.000593375,0.0001274155,0.00004394869,0.0002325047,0.0006551002,0.0006922556,0.0000260509,0.001234713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0344072,"threshold_uncertainty_score":0.8826066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0560335684438591,"score_gpt":0.3495175945289421,"score_spread":0.293484026085083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}