{"id":"W1990262754","doi":"10.1016/s0891-5849(99)00197-5","title":"Modulation of endoplasmic reticulum-bound cholesterol regulatory enzymes by iron/ascorbate-mediated lipid peroxidation","year":2000,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Lipid peroxidation; Cholesterol; Biochemistry; Endoplasmic reticulum; Reductase; Sterol O-acyltransferase; Chemistry; Sterol; Enzyme; Microsome; Polyunsaturated fatty acid; HMG-CoA reductase; Internal medicine; Endocrinology; Biology; Fatty acid; Lipoprotein; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002986482,0.0001922681,0.0005170288,0.0001012349,0.00007834156,0.000002182393,0.00009655509,0.0003284398,0.001205153],"category_scores_gemma":[0.0001038757,0.0001343335,0.00005200539,0.0001389954,0.001005839,0.00005413116,0.000009629626,0.0002322561,0.00001139448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002135523,"about_ca_system_score_gemma":0.00004468773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005489512,"about_ca_topic_score_gemma":0.00002125607,"domain_scores_codex":[0.9986632,0.00007098119,0.0004650123,0.000339691,0.0002049199,0.0002561473],"domain_scores_gemma":[0.9992241,0.00009148692,0.0001053002,0.0003123414,0.00004459893,0.0002221815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00121733,0.0003116678,0.02721817,0.0003146631,0.0001408796,0.00002131032,0.0005862197,0.000003324235,0.9260071,0.003168809,0.009143652,0.03186689],"study_design_scores_gemma":[0.03306429,0.006069463,0.5685484,0.001561044,0.001043845,0.0003309835,0.0003539406,0.001565079,0.2463898,0.004107574,0.1361092,0.0008564178],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909993,0.002821006,0.0003410342,0.004111806,0.0002279599,0.0003219554,0.00004066305,0.00005929563,0.001077007],"genre_scores_gemma":[0.9948323,0.001704417,0.0001756062,0.000649461,0.0003118469,0.000013307,0.0008303405,0.00001653628,0.001466118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6796173,"threshold_uncertainty_score":0.9997079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00638666353813057,"score_gpt":0.2367924454171449,"score_spread":0.2304057818790144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}