{"id":"W1990262754","doi":"10.1016/s0891-5849(99)00197-5","title":"Modulation of endoplasmic reticulum-bound cholesterol regulatory enzymes by iron/ascorbate-mediated lipid peroxidation","year":2000,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Lipid peroxidation; Cholesterol; Biochemistry; Endoplasmic reticulum; Reductase; Sterol O-acyltransferase; Chemistry; Sterol; Enzyme; Microsome; Polyunsaturated fatty acid; HMG-CoA reductase; Internal medicine; Endocrinology; Biology; Fatty acid; Lipoprotein; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000335353,0.0002996741,0.000305558,0.000211633,0.0002498819,0.0003497511,0.0002195387,0.000352092,0.0009838303],"category_scores_gemma":[0.0003008885,0.0001518813,0.0002614619,0.0001232986,0.0003527045,0.0003063724,0.0001866364,0.0004903837,0.0002030774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003342011,"about_ca_system_score_gemma":0.0002052246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006203611,"about_ca_topic_score_gemma":0.0006224532,"domain_scores_codex":[0.9998513,0.00004295543,0.00001032099,0.00002250878,0.00001714587,0.00005566241],"domain_scores_gemma":[0.9998521,0.00003388678,0.00002912739,0.00002660312,0.00002772514,0.00003060832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002707177,0.00008605485,0.0002923434,0.00004704048,0.00001423317,0.00009631914,0.00004951871,0.00004326177,0.9933554,0.000387666,0.00007927274,0.002841835],"study_design_scores_gemma":[0.000076859,0.0003685945,0.001865554,0.000004319488,0.00002257395,0.0001121907,0.00002821319,0.0005995788,0.9961066,0.0001329727,0.0006774779,0.00000515303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945105,0.0018378,0.002352636,0.0001927366,0.0000518304,0.00002722062,0.00006620383,0.00005629271,0.0009046484],"genre_scores_gemma":[0.9973398,0.0005706056,0.0008480285,0.00003665643,0.00001854027,0.00001190841,0.00008145632,0.000008020802,0.001084958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009838303,"threshold_uncertainty_score":0.003291249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00638666353813057,"score_gpt":0.2367924454171449,"score_spread":0.2304057818790144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}