{"id":"W1990266220","doi":"10.1016/j.bcp.2004.06.024","title":"Using yeast to screen for inhibitors of protein tyrosine phosphatase 1B","year":2004,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada); Concordia University","funders":"","keywords":"Vanadate; Saccharomyces cerevisiae; Protein tyrosine phosphatase; Yeast; Tyrosine kinase; EC50; Biochemistry; Growth inhibition; Phosphatase; Chemistry; IC50; High-throughput screening; Biology; Tyrosine; Enzyme; Cell growth; In vitro; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001491582,0.0002331307,0.0002612472,0.00006483333,0.00005694032,0.000008161243,0.0003132451,0.0002043526,0.00003104311],"category_scores_gemma":[0.0001464071,0.0002418958,0.0001291105,0.0001849235,0.0001829345,0.000005978186,0.000262392,0.00008647026,0.00001016186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005448032,"about_ca_system_score_gemma":0.0001749922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006860287,"about_ca_topic_score_gemma":0.000001019439,"domain_scores_codex":[0.9985715,0.00002687601,0.0003624566,0.0004924621,0.0001294916,0.0004171816],"domain_scores_gemma":[0.9992022,0.000009882032,0.0001367152,0.00026568,0.0001609736,0.0002245841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008058334,0.0002572445,0.00002008936,0.00005646218,0.00005570019,0.000002988746,0.000006446849,0.0001345902,0.9673513,0.0005819327,0.03052219,0.0002052458],"study_design_scores_gemma":[0.002779314,0.0005336552,0.00002505559,0.00003931065,0.0000547453,0.000009420203,0.000005883062,0.00001440687,0.9842836,0.000179587,0.01181067,0.0002643861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753833,0.01152381,0.009407808,0.0005023199,0.0002664248,0.001746908,0.001122938,0.00002677897,0.00001969065],"genre_scores_gemma":[0.9707379,0.00001661019,0.02713518,0.0007753329,0.0005796826,0.0002060059,0.000476998,0.00004430748,0.00002802764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01871152,"threshold_uncertainty_score":0.9864224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02398803669041394,"score_gpt":0.3182760053124923,"score_spread":0.2942879686220784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}