{"id":"W1990281333","doi":"10.1371/journal.ppat.1001209","title":"HapX Positively and Negatively Regulates the Transcriptional Response to Iron Deprivation in Cryptococcus neoformans","year":2010,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust","keywords":"Cryptococcus neoformans; Virulence; Biology; Siderophore; Aspergillus nidulans; Microbiology; Virulence factor; Gene; Mutant; Regulation of gene expression; Phenotype; Gene expression; Transcriptional regulation; GATA transcription factor; Cell biology; Genetics; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002663228,0.0001040923,0.0001370905,0.0001205272,0.0001930451,0.00001923368,0.00003517383,0.00005854481,0.00003879998],"category_scores_gemma":[0.0002670641,0.00007150281,0.00003771005,0.000201462,0.00008750759,0.00007182296,0.00002353721,0.0002154588,0.00001891537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003023757,"about_ca_system_score_gemma":0.00003234174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002194624,"about_ca_topic_score_gemma":0.000138647,"domain_scores_codex":[0.999317,0.00005525154,0.0001590709,0.0001701685,0.0001336429,0.0001648743],"domain_scores_gemma":[0.9995204,0.0001682116,0.00002628579,0.0001271506,0.00009118667,0.00006677236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005939505,0.0001010509,0.07703197,0.00001211034,0.0000196247,0.000009634454,0.0028942,0.000005750761,0.9178496,0.0006627791,0.00005400703,0.0007653136],"study_design_scores_gemma":[0.0005349088,0.0002701841,0.9755124,0.00003974281,0.00003625689,0.00002841359,0.0003292259,0.0002242019,0.02185338,0.0001639419,0.0009242969,0.00008307012],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935901,0.00004179083,0.00007863277,0.005086851,0.00007004163,0.0005424094,0.00003558709,0.00002984507,0.0005247699],"genre_scores_gemma":[0.9980708,0.00001721804,0.00109717,0.0003996807,0.00007182604,0.0000957712,0.000006483535,0.00001093297,0.0002300889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8984804,"threshold_uncertainty_score":0.29158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585307071095948,"score_gpt":0.2524894540316219,"score_spread":0.2366363833206624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}