{"id":"W1990314210","doi":"10.1038/sj.bjp.0706555","title":"Selectivity of imidazole–dioxolane compounds for<i>in vitro</i>inhibition of microsomal haem oxygenase isoforms","year":2005,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Microsome; Chemistry; Biochemistry; In vitro; Nitric oxide synthase; Oxygenase; Heme oxygenase; Microsoma; Enzyme; Stereochemistry; Heme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005660687,0.0001362439,0.0004251855,0.000110182,0.0000373092,0.000008811092,0.0001664895,0.0001693069,0.00002738001],"category_scores_gemma":[0.0000449061,0.0001596892,0.0002476262,0.0001080598,0.000119566,0.00001798738,0.00004780899,0.0002001121,5.308188e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004245478,"about_ca_system_score_gemma":0.0001840753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004283473,"about_ca_topic_score_gemma":0.0001530192,"domain_scores_codex":[0.9985154,0.0001059378,0.000755963,0.0001853341,0.0001346416,0.000302684],"domain_scores_gemma":[0.9989921,0.00003986998,0.0005082331,0.00006764445,0.0003003719,0.00009171506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00130755,0.0004383502,0.0002469624,0.00005748109,0.0001078951,0.00004327036,0.00003753314,0.0001713752,0.9860431,0.0000034053,0.005211634,0.006331449],"study_design_scores_gemma":[0.004239249,0.0004868197,0.001187587,0.00004374493,0.00005880313,0.001068081,0.00004116902,0.0001091232,0.9898443,0.00002856828,0.002748521,0.0001440784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964921,0.00193502,0.0007780692,0.0001557373,0.0002000955,0.0001905747,0.0001089358,0.000002949392,0.0001364555],"genre_scores_gemma":[0.9969489,0.0004643199,0.00167933,0.0002556573,0.0005323856,0.00000923848,0.000040901,0.00002031949,0.00004892447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006187371,"threshold_uncertainty_score":0.6511938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007033564954255339,"score_gpt":0.2600268662157215,"score_spread":0.2529933012614662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}