{"id":"W1990318883","doi":"10.1074/jbc.m114.600916","title":"Histone Deacetylase 6 Is a FoxO Transcription Factor-dependent Effector in Skeletal Muscle Atrophy","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"Institut National Du Cancer; Centre National de la Recherche Scientifique","keywords":"Effector; Histone deacetylase; Transcription factor; Histone deacetylase 5; Histone deacetylase 2; Skeletal muscle; Atrophy; Muscle atrophy; Histone; Cell biology; Cancer research; Biology; Medicine; Chemistry; Endocrinology; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002314838,0.0001848055,0.0002904345,0.00002651106,0.00004059895,0.000009140256,0.0002331068,0.0003729256,0.0002006523],"category_scores_gemma":[0.0001793624,0.0001412656,0.000268418,0.00005728795,0.0001258606,0.000006168838,0.00004228164,0.000293166,0.000008088914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003290308,"about_ca_system_score_gemma":0.0000371047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005724,"about_ca_topic_score_gemma":0.00000255026,"domain_scores_codex":[0.9988925,0.0000903391,0.0003839047,0.0002629224,0.000123544,0.0002467283],"domain_scores_gemma":[0.999388,0.00003239306,0.0002083987,0.0001808864,0.00006404454,0.0001263104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002456163,0.0001785491,0.001099978,0.00003274826,0.00002810933,0.000006904743,0.00002601655,0.0000214101,0.9948203,0.000004353938,0.0003302166,0.003205788],"study_design_scores_gemma":[0.002340261,0.001181914,0.0327649,0.00002832725,0.00001891022,0.00005357299,0.00005013121,0.0000277386,0.9509229,0.0003340993,0.01197555,0.0003016613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973514,0.0009029395,0.0009477569,0.0001448892,0.0001197481,0.00006181371,0.00001497927,0.000006122865,0.0004503488],"genre_scores_gemma":[0.998853,0.000233246,0.0001554285,0.0003173926,0.0003384619,0.00000483163,0.00002944846,0.00001012728,0.0000580092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04389738,"threshold_uncertainty_score":0.5760643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183885252023308,"score_gpt":0.2525327138284535,"score_spread":0.2406938613082204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}