{"id":"W1990318883","doi":"10.1074/jbc.m114.600916","title":"Histone Deacetylase 6 Is a FoxO Transcription Factor-dependent Effector in Skeletal Muscle Atrophy","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"Institut National Du Cancer; Centre National de la Recherche Scientifique","keywords":"Effector; Histone deacetylase; Transcription factor; Histone deacetylase 5; Histone deacetylase 2; Skeletal muscle; Atrophy; Muscle atrophy; Histone; Cell biology; Cancer research; Biology; Medicine; Chemistry; Endocrinology; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001752056,0.0003882335,0.0003427694,0.00026599,0.0003258733,0.0002118682,0.0002446854,0.0003433491,0.002846418],"category_scores_gemma":[0.00008886339,0.0001141293,0.0005417397,0.0002502586,0.0002604247,0.0001742071,0.0003680012,0.0004830311,0.0009788959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004061133,"about_ca_system_score_gemma":0.0002687433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00100442,"about_ca_topic_score_gemma":0.001415486,"domain_scores_codex":[0.9998714,0.00001229555,0.000009645991,0.00003917225,0.00003751964,0.0000299259],"domain_scores_gemma":[0.9999453,0.000002029949,0.00001649677,0.000003165448,0.00001309495,0.00002000802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001237518,0.0001370828,0.007433867,0.001396439,0.0001650531,0.0008105393,0.0001250143,0.0003027572,0.90527,0.002256851,0.008910909,0.07195415],"study_design_scores_gemma":[0.000625486,0.001925355,0.169459,0.000387254,0.0005256002,0.004956524,0.0002872749,0.001937034,0.4745272,0.003369875,0.3419257,0.00007371773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6118839,0.2886212,0.02550067,0.004693404,0.003114837,0.0003864155,0.006815916,0.002279553,0.05670411],"genre_scores_gemma":[0.8977583,0.05334118,0.005372697,0.001059049,0.0003736678,0.0001449828,0.005833765,0.00008963414,0.03602659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002846418,"threshold_uncertainty_score":0.0095222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183885252023308,"score_gpt":0.2525327138284535,"score_spread":0.2406938613082204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}