{"id":"W1990327207","doi":"10.1016/j.pain.2010.12.035","title":"A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain","year":2011,"lang":"en","type":"article","venue":"Pain","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of Calgary; Celator Pharmaceuticals (Canada); University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Neuropathic pain; Nociceptor; Sodium channel; Allodynia; Nociception; Spinal cord; Voltage-dependent calcium channel; Hyperalgesia; Transient receptor potential channel; Calcium channel; Pharmacology; Neuroscience; Ion channel; Medicine; Chemistry; Calcium; Internal medicine; Receptor; Sodium; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004268594,0.0001949657,0.0002333488,0.0001166279,0.0001023198,0.00001211395,0.00007718551,0.00009315999,0.0001654932],"category_scores_gemma":[0.0005560211,0.0001633128,0.00009144669,0.0001910583,0.00002725811,0.0000742806,0.00002422834,0.0001489293,0.0001348954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007087119,"about_ca_system_score_gemma":0.0000284412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007220465,"about_ca_topic_score_gemma":0.00000287433,"domain_scores_codex":[0.9983523,0.0005785144,0.0002120852,0.0003379334,0.0002272428,0.0002918857],"domain_scores_gemma":[0.9990298,0.0003199875,0.00008514995,0.0003374098,0.00007663533,0.0001509955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007444056,0.00465796,0.02597251,0.0003295832,0.00050397,0.0006369325,0.005737436,0.00001446891,0.6857598,0.008673763,0.003577898,0.2633913],"study_design_scores_gemma":[0.01826963,0.006708817,0.3673294,0.002248151,0.0006521412,0.0003442044,0.003883823,0.2675309,0.286444,0.02029733,0.02334299,0.002948549],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2627991,0.0004673284,0.7301801,0.001453826,0.0005449714,0.001109456,0.00002062703,0.0003778198,0.0030468],"genre_scores_gemma":[0.9938003,0.00003708409,0.003834705,0.001331432,0.0002006292,0.00007072341,0.00003674739,0.00004445445,0.0006439028],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7310012,"threshold_uncertainty_score":0.6659703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04963509478146279,"score_gpt":0.2364528499673173,"score_spread":0.1868177551858545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}