{"id":"W1990327207","doi":"10.1016/j.pain.2010.12.035","title":"A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain","year":2011,"lang":"en","type":"article","venue":"Pain","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of Calgary; Celator Pharmaceuticals (Canada); University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Neuropathic pain; Nociceptor; Sodium channel; Allodynia; Nociception; Spinal cord; Voltage-dependent calcium channel; Hyperalgesia; Transient receptor potential channel; Calcium channel; Pharmacology; Neuroscience; Ion channel; Medicine; Chemistry; Calcium; Internal medicine; Receptor; Sodium; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009522403,0.0004082011,0.0005622845,0.0002242089,0.0001514475,0.0002455951,0.0004963207,0.0003259572,0.001129583],"category_scores_gemma":[0.0001157953,0.0001257071,0.0002462347,0.0002011219,0.0002288756,0.0002371346,0.0001641861,0.0006139626,0.000276357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001428036,"about_ca_system_score_gemma":0.0002752153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004081287,"about_ca_topic_score_gemma":0.00106278,"domain_scores_codex":[0.9999419,0.00000739631,0.000005574919,0.00001114793,0.00001363604,0.00002037034],"domain_scores_gemma":[0.9999614,0.000004836785,0.00001282822,0.000003188607,0.000005767735,0.00001203569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006834443,0.0002621956,0.0001644254,0.0001070118,0.00001838388,0.0001164795,0.00001944185,0.0001676677,0.986108,0.0002275969,0.0001493309,0.01197614],"study_design_scores_gemma":[0.001634631,0.01094428,0.004787679,0.00001776644,0.0001662769,0.001161041,0.00004291439,0.00223869,0.973316,0.0001779437,0.00548241,0.00003039049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933035,0.001401744,0.003159607,0.0001597252,0.00003654465,0.0001374328,0.0001537779,0.0001723841,0.001475266],"genre_scores_gemma":[0.9925624,0.002326724,0.002871385,0.0001248233,0.00002942035,0.00009365682,0.0003623274,0.00002099086,0.001608293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001129583,"threshold_uncertainty_score":0.003778875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04963509478146279,"score_gpt":0.2364528499673173,"score_spread":0.1868177551858545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}