{"id":"W1990342716","doi":"10.1007/s00401-011-0924-x","title":"MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma","year":2011,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute; Deutsche Kinderkrebsstiftung","keywords":"Medulloblastoma; Sonic hedgehog; Cancer research; Gene knockdown; microRNA; Pathology; Hedgehog signaling pathway; GLI1; Biology; Vismodegib; Metastasis; Medicine; Cell culture; Internal medicine; Cancer; Cell biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001554466,0.0002476125,0.0002474977,0.0002561407,0.0002619397,0.0003679105,0.0002141281,0.0002123117,0.002411328],"category_scores_gemma":[0.0002112098,0.000225249,0.0002196608,0.0001194375,0.0002031947,0.0002150638,0.0002193134,0.0005642663,0.0007234856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004432867,"about_ca_system_score_gemma":0.0003313601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001687015,"about_ca_topic_score_gemma":0.002746791,"domain_scores_codex":[0.9998608,0.00002950333,0.00001232526,0.00002144663,0.00003180368,0.00004417062],"domain_scores_gemma":[0.9998935,0.00002478325,0.00001591777,0.00001701952,0.00001001716,0.00003868086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005714571,0.00009608363,0.0003550026,0.00003216177,0.000008911245,0.0002115543,0.00002367989,0.00008977272,0.9969419,0.000180403,0.0001569014,0.001332218],"study_design_scores_gemma":[0.00008044786,0.0006945775,0.007009868,0.000003575045,0.00003090212,0.0004611614,0.00007693501,0.001694971,0.9873661,0.00007793884,0.00249805,0.000005523731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964554,0.0005877295,0.000717609,0.00006035547,0.00004481159,0.00001619908,0.000133157,0.00006055934,0.00192426],"genre_scores_gemma":[0.9968581,0.0002308312,0.0003204251,0.00002249622,0.00000674696,0.00001778834,0.0001596483,0.00001430708,0.002369566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002411328,"threshold_uncertainty_score":0.008066714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02671988072394545,"score_gpt":0.2456234583995508,"score_spread":0.2189035776756053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}