{"id":"W1990391394","doi":"10.1002/jcp.22400","title":"pH control mechanisms of tumor survival and growth","year":2010,"lang":"en","type":"review","venue":"Journal of Cellular Physiology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":353,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"CHIST-ERA; Natural Sciences and Engineering Research Council of Canada; Ligue Contre le Cancer","keywords":"Tumor microenvironment; Warburg effect; Cancer cell; Biology; Carbonic anhydrase; Context (archaeology); Intracellular pH; Phenotype; Tumor hypoxia; Cellular adaptation; Cell; Cancer; Tumor progression; Metabolism; Cancer research; Cell biology; Intracellular; Enzyme; Biochemistry; Tumor cells; Genetics; Gene; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000272013,0.0007118661,0.001035853,0.001050036,0.0002560643,0.0008445829,0.0008798535,0.0008064105,0.001321411],"category_scores_gemma":[0.0001991313,0.0002009996,0.0002698142,0.0008410713,0.0007105597,0.0007901867,0.0005503555,0.001009367,0.001349175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008022747,"about_ca_system_score_gemma":0.0005496365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005929329,"about_ca_topic_score_gemma":0.0006336551,"domain_scores_codex":[0.9998567,0.00002118975,0.00001545012,0.00003298947,0.00005251156,0.00002098769],"domain_scores_gemma":[0.9999181,0.00002107499,0.00001793681,0.000005094435,0.00002358046,0.00001419515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001942627,0.00008237109,0.0003955487,0.009081527,0.00007970533,0.0005310507,0.0001314798,0.001169443,0.05377043,0.02057708,0.01321558,0.9007714],"study_design_scores_gemma":[0.00003230485,0.0002088691,0.002675076,0.0007923313,0.00007056001,0.001993923,0.0001224929,0.0004382246,0.0239315,0.009431928,0.9602625,0.00004026999],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009966935,0.9939373,0.001323084,0.0003129998,0.0001742869,0.000009579299,0.00003125915,0.00003316953,0.00318153],"genre_scores_gemma":[0.008926539,0.9880846,0.0006434154,0.000120007,0.0001780512,0.00002518509,0.00004511131,0.000004237983,0.001972849],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001321411,"threshold_uncertainty_score":0.00582099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130243575155948,"score_gpt":0.2456855069663935,"score_spread":0.234383071214834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}