{"id":"W1990413972","doi":"10.1002/em.10113","title":"Msh2 deficiency increases the mutation frequency in all parts of the mouse colon","year":2002,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"MSH2; Biology; Frameshift mutation; Mutation; Haploinsufficiency; Genetics; DNA mismatch repair; Mutant; Gene; MLH1; Molecular biology; Cancer research; DNA repair; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007354328,0.0001041802,0.0001155039,0.00002796532,0.00004783351,0.000004887388,0.00008259276,0.00004899869,0.0002346022],"category_scores_gemma":[0.0000275551,0.00006468326,0.00005697595,0.00006960549,0.0002020429,0.00001908142,0.0000644668,0.00006986019,0.000009875256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006533414,"about_ca_system_score_gemma":0.000007493868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001438024,"about_ca_topic_score_gemma":0.00002917691,"domain_scores_codex":[0.9992232,0.00007571507,0.0001635692,0.0001737594,0.0002275515,0.0001361591],"domain_scores_gemma":[0.9996495,0.00002831593,0.00005747404,0.0002198097,0.000002802861,0.00004211561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002395031,0.0002923979,0.09708661,0.00002723324,0.00002383819,0.00004345474,0.0007116897,0.0001562164,0.8981451,0.00001946421,0.00007763426,0.003392445],"study_design_scores_gemma":[0.0008083584,0.0002982386,0.5030615,0.00002118609,0.0001284884,0.00009324063,0.0003512612,0.0002662263,0.4942465,0.00009629195,0.0004890338,0.0001397088],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952427,0.003604627,0.00001578351,0.000345967,0.00003283687,0.0003726413,0.00001311842,0.000005748451,0.0003666184],"genre_scores_gemma":[0.9987898,0.0003238115,0.0001156198,0.0005745472,0.000008135326,0.00003877997,0.000007252727,0.0000129179,0.0001290688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4059749,"threshold_uncertainty_score":0.2637707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01302958292878501,"score_gpt":0.2146058549360319,"score_spread":0.2015762720072469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}