{"id":"W1990428105","doi":"10.1038/cr.2015.37","title":"TREM2 enables amyloid β clearance by microglia","year":2015,"lang":"en","type":"letter","venue":"Cell Research","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"TREM2; Microglia; Biology; Myeloid cells; Innate immune system; Receptor; Amyloid (mycology); Immunology; Amyloid β; Immunity; Phagocytosis; Cell biology; Myeloid; Neuroscience; Disease; Inflammation; Immune system; Genetics; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001047894,0.0003849918,0.0003546541,0.0004830125,0.0004742879,0.0005305341,0.001325299,0.0006001927,0.0009248072],"category_scores_gemma":[0.0006652111,0.0003739994,0.0001219494,0.0007362216,0.0003247352,0.0002090029,0.0002971904,0.004011169,0.006474796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001406805,"about_ca_system_score_gemma":0.0003744064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001496799,"about_ca_topic_score_gemma":0.000002299529,"domain_scores_codex":[0.9927349,0.001795697,0.0004431807,0.001348228,0.002519456,0.0011585],"domain_scores_gemma":[0.9975247,0.0006622677,0.00015272,0.001039575,0.0003696434,0.0002510418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001389988,0.00001982885,1.16404e-7,0.00005244352,5.664534e-7,0.000239001,0.00002865945,0.000001777118,0.4817056,0.00003362604,0.5176361,0.0002683542],"study_design_scores_gemma":[0.0001920125,0.00007182236,8.911523e-8,0.00001057159,0.00000185349,0.00001223984,0.000004750051,0.00007868604,0.4928227,0.0002277933,0.5064062,0.0001711921],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.02084994,0.001077961,0.0001796172,0.8354129,0.002952815,0.002707468,0.0005995078,0.0007626342,0.1354571],"genre_scores_gemma":[0.003035968,0.0008570163,0.00008493583,0.4426306,0.002513382,0.0001227511,0.0001459076,0.0002195037,0.5503899],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.4149328,"threshold_uncertainty_score":0.9999885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1577841503982622,"score_gpt":0.3489024151395931,"score_spread":0.1911182647413309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}