{"id":"W1990507217","doi":"10.1038/nrc1631","title":"Antisense therapy for cancer","year":2005,"lang":"en","type":"review","venue":"Nature reviews. Cancer","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":399,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"","keywords":"Cancer; Nuclease; Antisense therapy; Oligonucleotide; Cancer research; Biology; Gene; Genetic enhancement; Cancer cell; Computational biology; Bioinformatics; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0002852716,0.0005361398,0.001413966,0.00006441012,0.00008954661,0.00002865869,0.00027758,0.001484774,0.0001823098],"category_scores_gemma":[0.00003640647,0.0003586244,0.001093899,0.0001664669,0.00003002097,0.000003258312,0.00004830413,0.0004128341,0.0000124303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008277351,"about_ca_system_score_gemma":0.0003481403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001003984,"about_ca_topic_score_gemma":0.00007845479,"domain_scores_codex":[0.9981694,0.0001057664,0.0005403878,0.0007090371,0.0001420529,0.0003333167],"domain_scores_gemma":[0.9987373,0.00001826766,0.0004953221,0.0005370575,0.000124852,0.00008723544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001208041,0.00002020274,2.864633e-7,0.004530104,0.0001409262,4.881183e-7,0.000002944002,0.000001377967,0.0002449926,0.00004872081,0.02572608,0.9692718],"study_design_scores_gemma":[0.000264308,0.00005551857,7.752049e-7,0.005402308,0.0004100071,0.000009675859,3.973682e-7,0.000002225078,0.0001639849,0.000008341322,0.9932254,0.0004570499],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000001503033,0.9951802,0.000154511,0.00007887949,0.001332554,0.002816009,0.0002966381,0.00001384588,0.0001258696],"genre_scores_gemma":[0.000001313037,0.9863111,0.0006214449,0.0006145897,0.004766043,0.002025456,0.0008208102,0.0001120384,0.004727247],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9688147,"threshold_uncertainty_score":0.9998866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0441429174720454,"score_gpt":0.416710876922098,"score_spread":0.3725679594500526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}