{"id":"W1990518792","doi":"10.1073/pnas.1013555107","title":"Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by α-crystallin-B","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Toronto General Hospital; Heart and Stroke Foundation; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Calcineurin; Endoplasmic reticulum; Apoptosis; Cell biology; Biology; Proteome; Unfolded protein response; Transcriptome; ATF6; Molecular biology; Biochemistry; Transplantation; Gene expression; Internal medicine; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002303147,0.0003325364,0.0003043047,0.0003044281,0.0001854993,0.0002711877,0.0002234541,0.0002584927,0.0005354196],"category_scores_gemma":[0.0001548515,0.0001549596,0.0002785579,0.0002049942,0.0002710959,0.0001798563,0.0001925685,0.000588724,0.0001451623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002399535,"about_ca_system_score_gemma":0.0002613071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005714085,"about_ca_topic_score_gemma":0.000840301,"domain_scores_codex":[0.9998265,0.00002312252,0.00002387601,0.0000392195,0.00005061995,0.00003664487],"domain_scores_gemma":[0.9997781,0.00003348012,0.00007504791,0.00003229747,0.00001927566,0.00006173661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006130842,0.00001354689,0.00009774622,0.00001270986,0.00000340343,0.00001894691,0.000005718724,0.00001538162,0.9995149,0.00001682382,0.000008382948,0.000230921],"study_design_scores_gemma":[0.00003555774,0.0004447775,0.01214135,0.000008003401,0.00002106188,0.0003175695,0.00003287223,0.001329433,0.9845731,0.00006201823,0.00102868,0.000005672064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969963,0.0008581617,0.001320714,0.00008544888,0.00002202409,0.00002199386,0.0002314432,0.00006361271,0.0004003453],"genre_scores_gemma":[0.9958094,0.0007391931,0.001622047,0.00006458594,0.00001139853,0.00004213338,0.0005927127,0.00001927679,0.001099233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005714085,"threshold_uncertainty_score":0.001791179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02032960569051562,"score_gpt":0.2682139086709771,"score_spread":0.2478843029804615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}