{"id":"W1990559461","doi":"10.1016/s0166-6851(03)00102-6","title":"Haemonchus contortus: HcGluCla expressed in Xenopus oocytes forms a glutamate-gated ion channel that is activated by ibotenate and the antiparasitic drug ivermectin","year":2003,"lang":"en","type":"article","venue":"Molecular and Biochemical Parasitology","topic":"Parasite Biology and Host Interactions","field":"Environmental Science","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Haemonchus contortus; Biology; Homomeric; Xenopus; Chloride channel; Nematode; Glutamate receptor; Ivermectin; Ion channel; Pharmacology; Antiparasitic agent; Caenorhabditis elegans; Biochemistry; Zoology; Gene; Receptor; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000189934,0.0002493157,0.0003444569,0.00004486536,0.00017185,0.00002952533,0.0001523714,0.000261775,0.00008500771],"category_scores_gemma":[0.00009068893,0.0001729309,0.00006156947,0.0001621687,0.0008545713,0.0001023507,0.00007738017,0.0003006747,0.00002825195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004868712,"about_ca_system_score_gemma":0.000008062524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004415167,"about_ca_topic_score_gemma":0.00003213938,"domain_scores_codex":[0.9984701,0.0002531733,0.0002307695,0.0005085392,0.0001103507,0.0004270429],"domain_scores_gemma":[0.9994038,0.0001725504,0.00009797346,0.0001973858,0.000009293769,0.000118969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004289209,0.00009652165,0.04009474,0.000005770614,0.00005158439,0.00004245071,0.0003461624,0.000005286847,0.9578375,0.0001275747,0.0007835396,0.0001799341],"study_design_scores_gemma":[0.002015975,0.00005035783,0.01657029,0.00001537431,0.000041147,0.0001601696,0.0001347034,0.0002381888,0.9779775,0.001420257,0.00113275,0.0002433191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962224,0.0008113802,0.0001035679,0.001066646,0.00008797235,0.0003201823,0.0000223695,0.00003036224,0.001335069],"genre_scores_gemma":[0.9986055,0.0001779425,0.00003601711,0.0009833983,0.00000603863,0.00003427971,0.00003215447,0.00001199367,0.0001126207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02352445,"threshold_uncertainty_score":0.7051919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006474411597857951,"score_gpt":0.26866647604167,"score_spread":0.262192064443812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}