{"id":"W1990559461","doi":"10.1016/s0166-6851(03)00102-6","title":"Haemonchus contortus: HcGluCla expressed in Xenopus oocytes forms a glutamate-gated ion channel that is activated by ibotenate and the antiparasitic drug ivermectin","year":2003,"lang":"en","type":"article","venue":"Molecular and Biochemical Parasitology","topic":"Parasite Biology and Host Interactions","field":"Environmental Science","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Haemonchus contortus; Biology; Homomeric; Xenopus; Chloride channel; Nematode; Glutamate receptor; Ivermectin; Ion channel; Pharmacology; Antiparasitic agent; Caenorhabditis elegans; Biochemistry; Zoology; Gene; Receptor; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001254679,0.0001908399,0.0001654184,0.0001239786,0.0001828545,0.0003624365,0.0002342821,0.0002868836,0.001895328],"category_scores_gemma":[0.000130308,0.0001669198,0.0001595548,0.000103445,0.0002701928,0.0003208554,0.0002318829,0.0004099706,0.000835845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005840236,"about_ca_system_score_gemma":0.0002315345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001989141,"about_ca_topic_score_gemma":0.00348895,"domain_scores_codex":[0.9999349,0.000008269358,0.000007105081,0.00001298314,0.00001484944,0.00002176406],"domain_scores_gemma":[0.999916,0.00001993926,0.00002425977,0.000009296107,0.00001069423,0.00001981077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006090532,0.000006949005,0.0001842155,0.00002379405,0.000002326254,0.00004235438,0.00001817261,0.00002420773,0.998926,0.0002087029,0.00007506222,0.0004273206],"study_design_scores_gemma":[0.00003777719,0.00009070316,0.004352441,0.00001111387,0.00001068893,0.000318187,0.00005947188,0.001129562,0.9879467,0.00005494871,0.005981912,0.000006535139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914038,0.0007632115,0.003954966,0.0003152297,0.00005662774,0.00003688733,0.0005462328,0.0002023119,0.002720676],"genre_scores_gemma":[0.9864209,0.0004903466,0.003572991,0.0001012902,0.00002254339,0.00002883296,0.001648067,0.00007947942,0.007635576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001989141,"threshold_uncertainty_score":0.006340563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006474411597857951,"score_gpt":0.26866647604167,"score_spread":0.262192064443812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}