{"id":"W1990574610","doi":"10.1002/cbic.201200619","title":"A Synthetic, Species‐Specific Activator of Secondary Metabolism and Sporulation in <i>Streptomyces coelicolor</i>","year":2012,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Secondary metabolism; Streptomyces coelicolor; Streptomyces; Actinomycetales; Biochemistry; Metabolism; Biology; Small molecule; Streptomycetaceae; Actinorhodin; Bacteria; Secondary metabolite; Microbial metabolism; Biosynthesis; Computational biology; Chemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001870548,0.000136625,0.0003358825,0.00009089762,0.00002244874,0.000008314314,0.00005043423,0.0001177786,0.0004350759],"category_scores_gemma":[0.00008671307,0.0001082955,0.000056355,0.0001894902,0.0001127816,0.0001227647,0.00004472652,0.0001595575,0.000009322513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003109459,"about_ca_system_score_gemma":0.00002761214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001072928,"about_ca_topic_score_gemma":8.095694e-7,"domain_scores_codex":[0.9991724,0.000015446,0.0002467395,0.0002190276,0.0001219158,0.0002244899],"domain_scores_gemma":[0.9994853,0.00004439021,0.00009961049,0.0002171385,0.00005188245,0.0001017031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001301544,0.0001532569,0.003896796,0.0001200855,0.0000214478,0.000001349576,0.0002384845,1.342115e-8,0.9862104,0.000207066,0.001596614,0.007424318],"study_design_scores_gemma":[0.0004921228,0.00001686041,0.08196356,0.00006527392,0.00003068768,0.00002294598,0.0001611126,7.749259e-7,0.8697727,0.00001411599,0.047359,0.0001008825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896898,0.005141273,0.000001078479,0.000729354,0.0001228887,0.0002232463,0.0000136647,0.00001888096,0.004059845],"genre_scores_gemma":[0.998291,0.0003206692,0.0004285313,0.0001259319,0.00030196,0.000001370569,0.00001762173,0.00001427035,0.000498638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1164377,"threshold_uncertainty_score":0.4763776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01523800282220581,"score_gpt":0.2297531712385551,"score_spread":0.2145151684163493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}