{"id":"W1990574610","doi":"10.1002/cbic.201200619","title":"A Synthetic, Species‐Specific Activator of Secondary Metabolism and Sporulation in <i>Streptomyces coelicolor</i>","year":2012,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Secondary metabolism; Streptomyces coelicolor; Streptomyces; Actinomycetales; Biochemistry; Metabolism; Biology; Small molecule; Streptomycetaceae; Actinorhodin; Bacteria; Secondary metabolite; Microbial metabolism; Biosynthesis; Computational biology; Chemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000154247,0.0003444451,0.0002147652,0.0002272617,0.0001367532,0.0002259875,0.0001755572,0.0001905036,0.001146479],"category_scores_gemma":[0.0001319998,0.0001060772,0.0002155216,0.0001928958,0.0001962062,0.00009595553,0.0001376485,0.0003479354,0.0002763099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002529499,"about_ca_system_score_gemma":0.00025924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008183094,"about_ca_topic_score_gemma":0.001312533,"domain_scores_codex":[0.9998462,0.00004479279,0.00001542045,0.0000243231,0.0000371123,0.0000321409],"domain_scores_gemma":[0.9998885,0.00002358966,0.00003041842,0.00001218898,0.000008271806,0.00003704911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001993719,0.00003365255,0.0001101324,0.00003629534,0.000003365115,0.00003743445,0.000006934973,0.0001747621,0.9979685,0.00006836738,0.00002180619,0.001339469],"study_design_scores_gemma":[0.00002466708,0.0006787712,0.001465938,0.000003734935,0.000008152303,0.0001241659,0.00001086285,0.0003617044,0.9956719,0.00001922086,0.001627261,0.000003578661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988581,0.002448708,0.003536773,0.0001114272,0.00003967758,0.00007504012,0.0006772573,0.0001690887,0.004360981],"genre_scores_gemma":[0.9922347,0.0008760695,0.004126944,0.0000514417,0.00001168085,0.0000352185,0.0008717183,0.00002755102,0.001764627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001146479,"threshold_uncertainty_score":0.00383532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01523800282220581,"score_gpt":0.2297531712385551,"score_spread":0.2145151684163493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}