{"id":"W1990584739","doi":"10.1530/erc-13-0349","title":"Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome–wide interaction study","year":2013,"lang":"en","type":"article","venue":"Endocrine Related Cancer","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University of Toronto; Mount Sinai Hospital","funders":"National Cancer Institute; Universitätsklinikum Hamburg-Eppendorf; Cancer Council Tasmania; Canadian Institutes of Health Research; U.S. Army; Rheinische Friedrich-Wilhelms-Universität Bonn; National Health and Medical Research Council; Institut National Du Cancer; Cancer Council Victoria; Deutsche Krebshilfe; National Institutes of Health; Deutsche Gesetzliche Unfallversicherung; CHIST-ERA; Agence Nationale de la Recherche; Bundesministerium für Bildung und Forschung; National Breast Cancer Foundation; Fondation de France; Deutsches Krebsforschungszentrum; Ligue Contre le Cancer; National Institute for Health and Care Research; Robert Bosch Stiftung; U.S. Department of Health and Human Services; Ovarian Cancer Research Fund; Medical Research and Materiel Command; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; McGill University; European Commission; Breast Cancer Research Foundation; Cancer Research UK","keywords":"Single-nucleotide polymorphism; Breast cancer; SNP; Genome-wide association study; Genetic association; Oncology; Medicine; Internal medicine; Biology; Genetics; Cancer; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004392003,0.001325981,0.002629136,0.00130784,0.0006624878,0.001852947,0.0009985351,0.001703652,0.002647294],"category_scores_gemma":[0.009017658,0.0007966093,0.01207443,0.002506468,0.0004688847,0.0005922827,0.00105892,0.001642236,0.0002028869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007322141,"about_ca_system_score_gemma":0.0007263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00853741,"about_ca_topic_score_gemma":0.01111993,"domain_scores_codex":[0.9959078,0.002010736,0.0004180442,0.0009832714,0.0003484416,0.000331686],"domain_scores_gemma":[0.9928471,0.004848568,0.001065117,0.0005550342,0.0003750219,0.0003091101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01817588,0.0002310556,0.4910051,0.004683778,0.4584278,0.0009877017,0.0002556191,0.001252727,0.004761883,0.0004082346,0.001205076,0.01860518],"study_design_scores_gemma":[0.001605766,0.001243789,0.5009449,0.0004479807,0.4887149,0.0007342617,0.0001508704,0.002158574,0.000775136,0.0008519965,0.002312878,0.00005904272],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7499299,0.2401792,0.003796329,0.001711456,0.0004099659,0.0001194671,0.002266393,0.0001460586,0.001441089],"genre_scores_gemma":[0.9850667,0.01109624,0.001838834,0.0005534653,0.0001646906,0.00009050743,0.0007519,0.00002710103,0.0004106764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00853741,"threshold_uncertainty_score":0.02322739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006269507330037659,"score_gpt":0.2549083017766176,"score_spread":0.2486387944465799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}