{"id":"W1990584739","doi":"10.1530/erc-13-0349","title":"Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome–wide interaction study","year":2013,"lang":"en","type":"article","venue":"Endocrine Related Cancer","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University of Toronto; Mount Sinai Hospital","funders":"National Cancer Institute; Universitätsklinikum Hamburg-Eppendorf; Cancer Council Tasmania; Canadian Institutes of Health Research; U.S. Army; Rheinische Friedrich-Wilhelms-Universität Bonn; National Health and Medical Research Council; Institut National Du Cancer; Cancer Council Victoria; Deutsche Krebshilfe; National Institutes of Health; Deutsche Gesetzliche Unfallversicherung; CHIST-ERA; Agence Nationale de la Recherche; Bundesministerium für Bildung und Forschung; National Breast Cancer Foundation; Fondation de France; Deutsches Krebsforschungszentrum; Ligue Contre le Cancer; National Institute for Health and Care Research; Robert Bosch Stiftung; U.S. Department of Health and Human Services; Ovarian Cancer Research Fund; Medical Research and Materiel Command; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; McGill University; European Commission; Breast Cancer Research Foundation; Cancer Research UK","keywords":"Single-nucleotide polymorphism; Breast cancer; SNP; Genome-wide association study; Genetic association; Oncology; Medicine; Internal medicine; Biology; Genetics; Cancer; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000088361,0.0002414804,0.0002430649,0.00007579135,0.00008666731,0.00002086847,0.0001157593,0.0001078527,0.000210899],"category_scores_gemma":[0.00001213768,0.0001974245,0.00005436829,0.0001398608,0.0000755656,0.00001216575,0.00008448528,0.0002614389,0.000009218385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005683168,"about_ca_system_score_gemma":0.00006312809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003308608,"about_ca_topic_score_gemma":0.00003773048,"domain_scores_codex":[0.9986125,0.000133126,0.0003531279,0.000436819,0.0001610422,0.0003033738],"domain_scores_gemma":[0.9992054,0.00001577186,0.0002320764,0.000314653,0.0001112384,0.0001208363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001181809,0.0004525307,0.1186829,0.00002211092,0.002036151,0.00001445561,0.0004960894,0.002688726,0.8463339,0.000003279627,0.001757434,0.02633065],"study_design_scores_gemma":[0.01179095,0.005326523,0.892629,0.00006656457,0.0004481506,0.0001998708,0.0007551808,0.001194681,0.08257078,0.00005386883,0.004134659,0.000829815],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9724342,0.02603294,0.00001790867,0.0001604801,0.0001862963,0.0009177674,0.00003154828,0.00002090818,0.0001978982],"genre_scores_gemma":[0.9637407,0.03507828,0.00004996226,0.00004444193,0.00009201712,0.0003724416,0.00001952347,0.00004011948,0.0005625003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7739461,"threshold_uncertainty_score":0.8050736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006269507330037659,"score_gpt":0.2549083017766176,"score_spread":0.2486387944465799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}