{"id":"W1990587627","doi":"10.1371/journal.pone.0095413","title":"Overrepresentation of Glutamate Signaling in Alzheimer's Disease: Network-Based Pathway Enrichment Using Meta-Analysis of Genome-Wide Association Studies","year":2014,"lang":"en","type":"review","venue":"PLoS ONE","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Northern California Institute for Research and Education; Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias; Johns Hopkins University; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Synarc; Comisión Nacional de Investigación Científica y Tecnológica; University of Southern California; Medpace; Translational Genomics Research Institute; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Genome-wide association study; Biology; Genetic association; Genetics; Disease; Locus (genetics); Glutamate receptor; Gene; Apolipoprotein E; Single-nucleotide polymorphism; Bioinformatics; Computational biology; Medicine; Genotype; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009669472,0.001922635,0.003165752,0.004072516,0.0006619516,0.002399408,0.001203637,0.0007436164,0.001173992],"category_scores_gemma":[0.01466567,0.0006356285,0.009586585,0.005630479,0.0005634836,0.001229628,0.001920059,0.001325216,0.0001225059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006061407,"about_ca_system_score_gemma":0.001061605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005871047,"about_ca_topic_score_gemma":0.009339345,"domain_scores_codex":[0.993848,0.003551349,0.0004790657,0.001548187,0.0003621499,0.0002111892],"domain_scores_gemma":[0.9900439,0.007273329,0.0007595976,0.001287351,0.0003596121,0.0002762816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004014076,0.00006409277,0.4935779,0.004133606,0.4472333,0.0004668368,0.0002577663,0.009749179,0.00551832,0.0007830884,0.001045587,0.03315618],"study_design_scores_gemma":[0.0006036604,0.0005480588,0.4296627,0.0006799708,0.5195994,0.00101093,0.000384859,0.03370966,0.00236101,0.007892096,0.003429553,0.0001180098],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7717649,0.1680276,0.05033779,0.001570917,0.0003969296,0.0001645232,0.005785107,0.0007735263,0.001178732],"genre_scores_gemma":[0.9762676,0.009696045,0.01164796,0.0001822651,0.00008592669,0.0001049183,0.001745859,0.00009348056,0.0001759597],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.009669472,"threshold_uncertainty_score":0.05113763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.293277898256422,"score_gpt":0.4032813164940509,"score_spread":0.1100034182376289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}