{"id":"W1990592215","doi":"10.1159/000335038","title":"Mutant &lt;i&gt;GBA1&lt;/i&gt; Expression and Synucleinopathy Risk: First Insights from Cellular and Mouse Models","year":2012,"lang":"en","type":"review","venue":"Neurodegenerative Diseases","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"South Australian Research and Development Institute","keywords":"Synucleinopathies; Glucocerebrosidase; Alpha-synuclein; Dementia with Lewy bodies; Biology; Neuroscience; Parkinson's disease; Loss function; Disease; Genetics; Medicine; Dementia; Internal medicine; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001113337,0.001171018,0.002518642,0.0004118862,0.000635444,0.0001898489,0.0003537452,0.0004926945,0.0001542416],"category_scores_gemma":[0.0004048633,0.0008659287,0.0004986573,0.0003708109,0.0004637193,0.0004867315,0.0006468178,0.0007792268,0.00006332512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001533056,"about_ca_system_score_gemma":0.0003249747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000441185,"about_ca_topic_score_gemma":0.00004416614,"domain_scores_codex":[0.9946817,0.001011134,0.0008201547,0.001674979,0.001049912,0.0007621621],"domain_scores_gemma":[0.9963052,0.0005492279,0.0004710595,0.001095008,0.0002502583,0.001329242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00193582,0.007729141,0.001557959,0.05810498,0.003167536,0.005090505,0.006005714,0.0001465888,0.1074656,0.002130477,0.00735308,0.7993127],"study_design_scores_gemma":[0.00373051,0.0008520798,0.0006811632,0.009285801,0.009493165,0.00008269135,0.00007854008,0.002263531,0.004411957,0.0003406608,0.9663395,0.002440375],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1362361,0.8590347,0.0001214626,0.00002564725,0.0001753388,0.002051727,0.002024529,0.0001291822,0.0002013924],"genre_scores_gemma":[0.07427548,0.9228154,0.0001304049,0.0000727273,0.0006079506,0.0003880542,0.001092589,0.0002601201,0.0003572621],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9589865,"threshold_uncertainty_score":0.9993792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03821265034620145,"score_gpt":0.2773429219660842,"score_spread":0.2391302716198827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}