{"id":"W1990604167","doi":"10.2174/156800908785699306","title":"Epigenetic Aberrations and Targeted Epigenetic Therapy of Esophageal Cancer","year":2008,"lang":"en","type":"review","venue":"Current Cancer Drug Targets","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Royal University Hospital","funders":"","keywords":"Epigenetics; Malignancy; Esophageal cancer; Biology; Esophagus; Disease; Epigenetic therapy; Cancer; Cancer research; Carcinogenesis; Somatic evolution in cancer; Bioinformatics; Carcinoma; Medicine; Genetics; Pathology; Internal medicine; Gene; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001377906,0.0006402807,0.001165899,0.0001771779,0.0001696432,0.00002428542,0.000347906,0.00034094,0.0001186288],"category_scores_gemma":[0.00003777383,0.0005723895,0.0004346157,0.0002720987,0.0002273408,0.000005766172,0.0001451876,0.0002923398,0.000005899424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006217926,"about_ca_system_score_gemma":0.0008588034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001191592,"about_ca_topic_score_gemma":0.0001128748,"domain_scores_codex":[0.9972878,0.0002489153,0.0008640505,0.0008558735,0.0002921618,0.000451252],"domain_scores_gemma":[0.9982803,0.00004199461,0.0006638683,0.0005793922,0.0002316923,0.000202679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001195949,0.0001099524,0.0005255202,0.001741238,0.0002685336,0.000001340491,0.0001333665,0.00008435512,0.001001091,0.000007545659,0.001364053,0.994751],"study_design_scores_gemma":[0.0004079106,0.00007618532,0.00053191,0.001187036,0.0001797638,0.000002187468,0.000004089592,0.00001373743,0.008250888,0.00004105013,0.9887363,0.0005689919],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003055449,0.9936811,0.0002111028,0.00002246369,0.001446634,0.001005905,0.0004988843,0.00001556857,0.00006283331],"genre_scores_gemma":[0.00243785,0.994702,0.0001684318,0.00001558277,0.0008177959,0.0006440763,0.000837559,0.0001077502,0.0002689717],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9941821,"threshold_uncertainty_score":0.9996728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04657069195341299,"score_gpt":0.3657157121025971,"score_spread":0.3191450201491841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}