{"id":"W1990622580","doi":"10.1016/j.ymthe.2005.09.014","title":"Hypersensitivity and Loss of Disease Site Targeting Caused by Antibody Responses to PEGylated Liposomes","year":2005,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":276,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovative Targeting Solutions (Canada)","funders":"","keywords":"Liposome; Biodistribution; Immunogenicity; Nucleic acid; Transfection; Pharmacology; PEGylation; Genetic enhancement; In vivo; Drug delivery; Gene delivery; Chemistry; Polyethylene glycol; Biology; Immunology; Biochemistry; In vitro; Immune system; Biotechnology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001201788,0.0001534102,0.0001500484,0.00004842826,0.00004563289,0.00001808425,0.0000878321,0.00007244143,0.00000951904],"category_scores_gemma":[0.00004794619,0.0001454671,0.0000732642,0.00007490463,0.00006341298,0.000005299483,0.00005509645,0.00004809115,0.000009804876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005744153,"about_ca_system_score_gemma":0.00003210448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002454769,"about_ca_topic_score_gemma":0.000004022716,"domain_scores_codex":[0.9991236,0.0001055592,0.0001567148,0.0003115255,0.0001105719,0.0001920667],"domain_scores_gemma":[0.9994686,0.00001104301,0.00005137737,0.0002523749,0.00008720985,0.0001294585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007140536,0.00006944919,0.005888215,0.000005761513,0.00006202064,0.00001749771,0.00009739495,0.00004632948,0.9897435,0.000003267871,0.0004180411,0.002934518],"study_design_scores_gemma":[0.0005192729,0.0003522526,0.009537861,0.00001444932,0.00001111527,0.000002929245,0.0000253711,0.00005632066,0.9775852,0.000005858303,0.01169364,0.0001957512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939725,0.00426391,0.0008276835,0.0006243705,0.00002779954,0.0001596871,0.00007443857,0.00001128646,0.000038318],"genre_scores_gemma":[0.9972366,0.0009172367,0.0002089651,0.001156585,0.00005135949,0.000005728848,0.0001488246,0.00002211538,0.0002525623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01215828,"threshold_uncertainty_score":0.5931977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007020304168869783,"score_gpt":0.2624446377240292,"score_spread":0.2554243335551594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}