{"id":"W1990622580","doi":"10.1016/j.ymthe.2005.09.014","title":"Hypersensitivity and Loss of Disease Site Targeting Caused by Antibody Responses to PEGylated Liposomes","year":2005,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":276,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovative Targeting Solutions (Canada)","funders":"","keywords":"Liposome; Biodistribution; Immunogenicity; Nucleic acid; Transfection; Pharmacology; PEGylation; Genetic enhancement; In vivo; Drug delivery; Gene delivery; Chemistry; Polyethylene glycol; Biology; Immunology; Biochemistry; In vitro; Immune system; Biotechnology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005277679,0.0004067282,0.0002201389,0.0002121138,0.00008455401,0.0002336376,0.000206779,0.0004624186,0.000855482],"category_scores_gemma":[0.0002823332,0.0001835867,0.0003260246,0.00009861676,0.000242335,0.0002707212,0.0002635887,0.0007252555,0.0002508424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002060927,"about_ca_system_score_gemma":0.0001106408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00020733,"about_ca_topic_score_gemma":0.0001155231,"domain_scores_codex":[0.99968,0.00007931631,0.00004497066,0.00006547619,0.00007132816,0.00005885104],"domain_scores_gemma":[0.9996887,0.00008134653,0.0001197539,0.00005732194,0.00002676718,0.00002600343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008722481,0.00002849117,0.0001722221,0.00003593113,0.000007027574,0.0001241704,0.00001793389,0.00009007064,0.998033,0.00007546612,0.00002432437,0.001304194],"study_design_scores_gemma":[0.00001859594,0.0006671667,0.001653749,0.000006050324,0.00001123116,0.0006534522,0.000007717809,0.0005331679,0.9955139,0.00004250957,0.0008876586,0.000004701691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832692,0.00241298,0.01248923,0.0001272158,0.00004340015,0.0001328747,0.0001154762,0.0001270828,0.001282506],"genre_scores_gemma":[0.9964499,0.0005268618,0.001709134,0.0001169555,0.000006720852,0.00003714275,0.0001092243,0.00001360367,0.001030373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000855482,"threshold_uncertainty_score":0.002861857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007020304168869783,"score_gpt":0.2624446377240292,"score_spread":0.2554243335551594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}