{"id":"W1990693523","doi":"10.1196/annals.1304.035","title":"Normalization of Up‐Regulated Cardiac Imidazoline I<sub>1</sub>‐Receptors and Natriuretic Peptides by Chronic Treatment with Moxonidine in Spontaneously Hypertensive Rats","year":2003,"lang":"en","type":"article","venue":"Annals of the New York Academy of Sciences","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Heart and Stroke Foundation of Canada","keywords":"Moxonidine; Atrial natriuretic peptide; Imidazoline receptor; Internal medicine; Receptor; Endocrinology; Natriuretic peptide; Brain natriuretic peptide; Agonist; Medicine; NPR2; Chemistry; Heart failure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001563503,0.0003437364,0.0005934612,0.0002616599,0.0001765348,0.0002937327,0.0002087658,0.0002876596,0.001094041],"category_scores_gemma":[0.0002093572,0.0002192701,0.0002390194,0.0001106553,0.0004324847,0.0002692111,0.0001599917,0.0009555808,0.0002820386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002789002,"about_ca_system_score_gemma":0.0002096351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008222873,"about_ca_topic_score_gemma":0.00190358,"domain_scores_codex":[0.9998192,0.00002839325,0.00001765988,0.00003381426,0.00003230878,0.00006870889],"domain_scores_gemma":[0.9997125,0.0000320311,0.00009982452,0.00003614715,0.00003150862,0.00008796177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007313407,0.00008911623,0.0002775715,0.00002582349,0.000007412191,0.00004159601,0.00001940832,0.00001937023,0.9970662,0.0000224475,0.00002590259,0.001673804],"study_design_scores_gemma":[0.0002222704,0.005000539,0.01927341,0.00001027766,0.00006104385,0.0002569868,0.0001030837,0.0004883338,0.973146,0.00003919379,0.001386796,0.00001218008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982306,0.0007234141,0.0004414645,0.00006798828,0.00002363402,0.00001162526,0.0001038455,0.00004914121,0.0003481803],"genre_scores_gemma":[0.9952266,0.0007640282,0.001250505,0.00007206155,0.00003829844,0.00005438381,0.0003140947,0.00002294014,0.002257042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001094041,"threshold_uncertainty_score":0.003659964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02020823131271718,"score_gpt":0.2514831209040174,"score_spread":0.2312748895913002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}