{"id":"W1990707608","doi":"10.1038/sj.onc.1208149","title":"TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3","year":2004,"lang":"en","type":"article","venue":"Oncogene","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Horowitz Foundation for Social Policy; Israel Cancer Association; Israel Cancer Research Fund","keywords":"Biology; F-box protein; C2C12; Golgi apparatus; Ubiquitin; Cytoplasm; Proteasome; Protein degradation; Cell biology; Ectopic expression; Tyrosine; Ubiquitin ligase; STAT3; Molecular biology; Biochemistry; Phosphorylation; Myocyte; Gene; Myogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001839718,0.0001065819,0.0001874143,0.00006808066,0.00008459362,0.00001399084,0.00007536315,0.00004920337,0.0003441254],"category_scores_gemma":[0.00009124476,0.00006962718,0.0001005475,0.0001524706,0.00004159398,0.00007795049,0.00002257016,0.0001440696,0.00004004386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008029094,"about_ca_system_score_gemma":0.0001810001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006386786,"about_ca_topic_score_gemma":0.00007964037,"domain_scores_codex":[0.9991942,0.00002145118,0.0002256096,0.0001543723,0.0002482987,0.0001560822],"domain_scores_gemma":[0.9993988,0.00004814485,0.0001391466,0.0002401998,0.0001120826,0.00006157623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001415493,0.0001392886,0.001343131,0.00003430828,0.00008421598,0.0000122805,0.001418088,0.00003561536,0.9881779,0.0007004693,0.000341452,0.007571679],"study_design_scores_gemma":[0.001093153,0.0005030832,0.0006569022,0.0002323225,0.00007660507,0.00003345434,0.000857449,0.00009436408,0.9878883,0.0003790721,0.008104925,0.00008041357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913354,0.0003426752,0.001693211,0.003660937,0.0001167632,0.0004076248,0.00002198004,0.00003705147,0.002384369],"genre_scores_gemma":[0.996821,0.00003967233,0.001742781,0.0004444836,0.0001462398,0.000044215,0.00003516148,0.0000183495,0.000708049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007763472,"threshold_uncertainty_score":0.3767932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04321149591835248,"score_gpt":0.2987707835620724,"score_spread":0.2555592876437199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}