{"id":"W1990707608","doi":"10.1038/sj.onc.1208149","title":"TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3","year":2004,"lang":"en","type":"article","venue":"Oncogene","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Horowitz Foundation for Social Policy; Israel Cancer Association; Israel Cancer Research Fund","keywords":"Biology; F-box protein; C2C12; Golgi apparatus; Ubiquitin; Cytoplasm; Proteasome; Protein degradation; Cell biology; Ectopic expression; Tyrosine; Ubiquitin ligase; STAT3; Molecular biology; Biochemistry; Phosphorylation; Myocyte; Gene; Myogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001796996,0.000623944,0.0003406724,0.0003766905,0.000409055,0.000378849,0.0003575264,0.0005292342,0.002948555],"category_scores_gemma":[0.0002146215,0.0001855659,0.0005228688,0.0001774647,0.0002748663,0.0003503578,0.0002669025,0.0008703202,0.002502186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005363898,"about_ca_system_score_gemma":0.0002637201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003310403,"about_ca_topic_score_gemma":0.0002547054,"domain_scores_codex":[0.999894,0.00001324636,0.000007228135,0.00002258445,0.00002836092,0.00003453682],"domain_scores_gemma":[0.9998154,0.00002049765,0.00006660135,0.00002242854,0.00002331608,0.00005175273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001916584,0.00002141147,0.0002079702,0.00003758414,0.00000521573,0.0001235863,0.000008516366,0.00003754674,0.9964551,0.0002610902,0.0002216556,0.002428865],"study_design_scores_gemma":[0.00004289183,0.0001875458,0.005770291,0.000008813485,0.00001131438,0.001826909,0.00003281428,0.00129653,0.9823088,0.0002839502,0.008217623,0.00001244735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792225,0.004202004,0.01020296,0.0003349183,0.0001482678,0.00006538235,0.001183986,0.0005840852,0.00405598],"genre_scores_gemma":[0.9800642,0.001241276,0.007037556,0.0001272751,0.00006836861,0.00005940246,0.00322135,0.00008961056,0.008091089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002948555,"threshold_uncertainty_score":0.009863913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04321149591835248,"score_gpt":0.2987707835620724,"score_spread":0.2555592876437199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}