{"id":"W1990709745","doi":"10.1006/jmbi.2001.5015","title":"Promoter suppression in cultured mammalian cells can be blocked by the chicken β-globin chromatin insulator 5′HS4 and matrix/scaffold attachment regions11Edited by M. Yaniv","year":2001,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Notre-Dame; Université de Montréal","funders":"National Cancer Institute; Bayer Canada; Medical Research Council Canada; Cancer Research Society","keywords":"Biology; Chromatin; Transgene; Transcription (linguistics); Scaffold/matrix attachment region; Gene; Insulator (electricity); Gene silencing; Cell biology; Promoter; Molecular biology; Genetics; Gene expression; Chromatin remodeling; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003376844,0.0002592684,0.0003173823,0.00007187612,0.0000841337,0.00003795072,0.0003802553,0.0003527198,0.00001489997],"category_scores_gemma":[0.00003871479,0.0001812338,0.0001241229,0.0001245274,0.0001367134,0.000005145935,0.0001650292,0.0002410635,9.080558e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004893566,"about_ca_system_score_gemma":0.00006890971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000555172,"about_ca_topic_score_gemma":0.00003885424,"domain_scores_codex":[0.9983868,0.000251273,0.0005626506,0.0003089279,0.0001447741,0.0003455561],"domain_scores_gemma":[0.9990021,0.00001370146,0.0004313272,0.0003200416,0.00009188086,0.0001409562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009611555,0.0001205257,0.001823577,0.00001140546,0.00007620289,0.0000332997,0.0001001456,0.00003039315,0.9809801,0.00002309158,0.01635579,0.0003493331],"study_design_scores_gemma":[0.00291477,0.001054318,0.001153445,0.00005413753,0.00007303106,0.0007720457,0.0002198965,0.0003176765,0.9042925,0.0003044961,0.0884214,0.0004222708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918216,0.003008131,0.0005746491,0.004015737,0.0001657857,0.0002809607,0.00008352858,0.000004338944,0.00004520866],"genre_scores_gemma":[0.9967309,0.0008030164,0.001120486,0.0007066609,0.0001124518,0.000009383004,0.0002142509,0.00003054918,0.00027236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0766876,"threshold_uncertainty_score":0.73905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004639971373705068,"score_gpt":0.2439228710819726,"score_spread":0.2392828997082676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}