{"id":"W1990721699","doi":"10.1016/j.ydbio.2009.10.014","title":"Regulation of Smoothened by Drosophila G-protein-coupled receptor kinases","year":2009,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Smoothened; G protein-coupled receptor; Cell biology; Biology; Hedgehog; Downregulation and upregulation; Signal transduction; Hedgehog signaling pathway; Protein kinase A; Receptor Protein-Tyrosine Kinases; Phosphorylation; Biochemistry; Receptor tyrosine kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001200455,0.000250813,0.0001218944,0.0002992986,0.0002272836,0.0003136954,0.0002113511,0.0001888329,0.0009403259],"category_scores_gemma":[0.0001459853,0.000186227,0.0001707089,0.0001145891,0.0002838745,0.0003566183,0.0003379026,0.0004087197,0.0002062283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005369295,"about_ca_system_score_gemma":0.0001437835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008753439,"about_ca_topic_score_gemma":0.001825061,"domain_scores_codex":[0.9999033,0.00001963698,0.000005816582,0.0000191305,0.00002131115,0.00003071112],"domain_scores_gemma":[0.9999032,0.00002223523,0.00002731553,0.00001452043,0.00001315088,0.00001957042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001632345,0.000005885256,0.0001775814,0.00001289612,0.000002379562,0.0000552531,0.00001090937,0.00004804535,0.9983668,0.0004003407,0.00001454066,0.0007420992],"study_design_scores_gemma":[0.00001230071,0.00007472785,0.01267765,0.000002832428,0.000007186009,0.0001287256,0.00004812147,0.0008920137,0.9844493,0.0001101887,0.001593452,0.000003444651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995119,0.001618532,0.0009840305,0.00006381619,0.00001364278,0.00001038437,0.0001045147,0.0000186648,0.002067491],"genre_scores_gemma":[0.9939361,0.0006700017,0.0007786831,0.00003283341,0.00000570299,0.00001062157,0.0002110791,0.00001378195,0.004341245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009403259,"threshold_uncertainty_score":0.00389576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01017449473689288,"score_gpt":0.2353982507144948,"score_spread":0.2252237559776019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}