{"id":"W1990759986","doi":"10.1002/pro.2128","title":"Multistate approaches in computational protein design","year":2012,"lang":"en","type":"review","venue":"Protein Science","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; University of Ottawa","keywords":"Protein design; Computational biology; Computer science; Chemistry; Protein structure; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001326512,0.0003970792,0.0005667194,0.0002264533,0.0001451805,0.00008940649,0.0008969778,0.0002952804,0.000007096883],"category_scores_gemma":[0.0001691858,0.0003279901,0.0001408782,0.0006547083,0.0005699907,0.00001881535,0.0003644011,0.000302502,0.00003082208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009356752,"about_ca_system_score_gemma":0.001036746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001268864,"about_ca_topic_score_gemma":0.000006762979,"domain_scores_codex":[0.9974641,0.0002092045,0.0004741416,0.0008179292,0.0004214777,0.0006131931],"domain_scores_gemma":[0.9989616,0.00001516799,0.000294979,0.0004979086,0.00007439629,0.0001559221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001363259,0.00005930656,0.000002766058,0.00193272,0.00001667884,0.000005247806,0.00002721016,0.0002129047,0.001774401,0.001375474,0.000005113137,0.9945745],"study_design_scores_gemma":[0.0007054603,0.0003159014,0.00002373854,0.004376316,0.0001154698,0.0001453155,0.00001820156,0.002061996,0.004720008,0.003959604,0.9815094,0.00204863],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008793882,0.9463501,0.04955569,0.00001262157,0.0000698988,0.003522177,0.0000272681,0.00001724531,0.0003570925],"genre_scores_gemma":[0.01253564,0.667604,0.3131188,0.00005161981,0.0006049257,0.004358066,0.0004237962,0.0001587676,0.001144372],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9925259,"threshold_uncertainty_score":0.9999172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1041386559686105,"score_gpt":0.3265163844407836,"score_spread":0.2223777284721732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}