{"id":"W1990759986","doi":"10.1002/pro.2128","title":"Multistate approaches in computational protein design","year":2012,"lang":"en","type":"review","venue":"Protein Science","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; University of Ottawa","keywords":"Protein design; Computational biology; Computer science; Chemistry; Protein structure; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001756822,0.00182927,0.001782869,0.001721912,0.0004972768,0.001795647,0.002757601,0.001810704,0.004101695],"category_scores_gemma":[0.002662299,0.001047325,0.001365624,0.002576854,0.00171938,0.001749923,0.001970688,0.003283258,0.002269369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001334865,"about_ca_system_score_gemma":0.001480945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001738125,"about_ca_topic_score_gemma":0.001552123,"domain_scores_codex":[0.9992458,0.0002782746,0.00006050001,0.0001236361,0.000256777,0.00003496987],"domain_scores_gemma":[0.9988255,0.0008292545,0.00004925229,0.0001029009,0.0001564644,0.00003661666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007100456,0.0001062886,0.0005063076,0.004987086,0.0003680587,0.0001349907,0.0001541182,0.2978033,0.001688838,0.2362626,0.01599674,0.4419205],"study_design_scores_gemma":[0.00009430442,0.0001129856,0.0002877378,0.001330223,0.00008945158,0.000214543,0.00006392115,0.3188218,0.002836602,0.3124506,0.3636083,0.0000896675],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.001650851,0.1966702,0.780483,0.001787232,0.0007946111,0.0001394709,0.0002364123,0.0008174434,0.01742071],"genre_scores_gemma":[0.04044523,0.2554954,0.6921029,0.0009321031,0.0008557636,0.001083294,0.0006909326,0.0004758205,0.007918582],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.004101695,"threshold_uncertainty_score":0.01372153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1041386559686105,"score_gpt":0.3265163844407836,"score_spread":0.2223777284721732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}