{"id":"W1990769245","doi":"10.3389/fonc.2014.00306","title":"Reduced Intracellular Drug Accumulation in Drug-Resistant Leukemia Cells is Not Only Solely Due to MDR-Mediated Efflux but also to Decreased Uptake","year":2014,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; Biotechnology and Biological Sciences Research Council; National Institutes of Health; Alberta Innovates; University of Manchester","keywords":"Efflux; Drug; Pharmacology; Intracellular; Multiple drug resistance; Drug resistance; Leukemia; Cancer research; Medicine; Chemistry; Biology; Internal medicine; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001294319,0.0004298067,0.001269218,0.0008997502,0.00008621916,0.00002304673,0.0003641791,0.0004560411,0.0001503333],"category_scores_gemma":[0.0002879558,0.0004208133,0.0001570614,0.0007683937,0.00009541508,0.00009087768,0.00005290372,0.0005708946,0.0001773706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001842948,"about_ca_system_score_gemma":0.001121532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008167549,"about_ca_topic_score_gemma":0.002636066,"domain_scores_codex":[0.9964107,0.0002650051,0.001059164,0.0008726527,0.0004886134,0.0009039257],"domain_scores_gemma":[0.9982209,0.0002017593,0.0001995001,0.0006060117,0.0001346955,0.0006370872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01099931,0.001007076,0.008639226,0.0003155912,0.0001583959,0.001365345,0.008768714,0.001475833,0.8266092,0.0003240782,0.1039454,0.03639178],"study_design_scores_gemma":[0.01723756,0.001451431,0.1137101,0.0008203725,0.0003089882,0.00003047482,0.00352998,0.008248856,0.4455317,0.0008777776,0.4068313,0.001421436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777997,0.0001456166,0.01106753,0.005085526,0.002518546,0.001619192,0.00004124682,0.0001062843,0.001616429],"genre_scores_gemma":[0.9547789,0.00004587298,0.03502511,0.004887384,0.0002956466,0.0001233497,0.0001743986,0.00008342174,0.004585953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3810775,"threshold_uncertainty_score":0.9998243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01355763183386895,"score_gpt":0.2715398408541725,"score_spread":0.2579822090203036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}