{"id":"W1990771269","doi":"10.1002/jmr.606","title":"Kinetic analysis of the interactions between Troponin C (TnC) and Troponin I (TnI) binding peptides: evidence for separate binding sites for the ‘structural’ N‐terminus and the ‘regulatory’ C‐terminus of TnI on TnC","year":2003,"lang":"en","type":"article","venue":"Journal of Molecular Recognition","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"National Institute of General Medical Sciences","keywords":"Chemistry; Troponin I; Troponin C; Biophysics; Dissociation constant; Ternary complex; Stereochemistry; Biochemistry; Receptor; Enzyme; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009685407,0.0001627883,0.0006221117,0.0003083339,0.000248006,0.00003640141,0.00008951271,0.00005192708,0.000005717364],"category_scores_gemma":[0.001241366,0.0000833992,0.0006028033,0.000383877,0.000282535,0.0001070981,0.00002800547,0.0001879162,1.912741e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005525025,"about_ca_system_score_gemma":0.00004528303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008988284,"about_ca_topic_score_gemma":0.0000093459,"domain_scores_codex":[0.9986132,0.0002278606,0.000577624,0.0001557806,0.0002708483,0.0001546197],"domain_scores_gemma":[0.9968668,0.001760013,0.0007865984,0.0001871371,0.0003499188,0.00004950832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01079752,0.0002211838,0.06628953,0.001401467,0.02452949,0.000111267,0.009675926,0.0009137146,0.7927686,0.0007653533,0.0007981125,0.09172782],"study_design_scores_gemma":[0.01612297,0.003268141,0.3060835,0.005229892,0.06568206,0.002467839,0.007801651,0.002924738,0.5865805,0.002503154,0.0007149598,0.0006205724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952261,0.001755789,0.001560909,0.0005369433,0.0001538876,0.0006742351,0.00005204422,0.000002981875,0.0000370531],"genre_scores_gemma":[0.998837,0.0002916973,0.0006102241,0.00006665224,0.00009785619,0.0000270908,0.000007540134,0.00001495305,0.00004696791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.239794,"threshold_uncertainty_score":0.3400921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06398777681073407,"score_gpt":0.3444083893570928,"score_spread":0.2804206125463587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}