{"id":"W1990800220","doi":"10.1021/cb100161u","title":"<i>N</i><sup>η</sup>-Substituted Arginyl Peptide Inhibitors of Protein Arginine <i>N</i>-Methyltransferases","year":2010,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; University of British Columbia; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Arginine; Peptide; Methylation; Guanidine; Chemistry; Active site; Methyltransferase; Stereochemistry; Moiety; Biochemistry; Binding site; Protein arginine methyltransferase 5; Residue (chemistry); Enzyme; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002301319,0.00033638,0.0002362838,0.00008759099,0.00007499233,0.0001194815,0.000286154,0.0002665645,0.001747312],"category_scores_gemma":[0.0001959262,0.00009947558,0.0001947119,0.0000662949,0.0001585396,0.0001691157,0.0001343585,0.0005068444,0.0005268586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001521993,"about_ca_system_score_gemma":0.0001152815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001965545,"about_ca_topic_score_gemma":0.000258204,"domain_scores_codex":[0.9998773,0.00003074595,0.00001002657,0.00001758849,0.00003424351,0.00003009336],"domain_scores_gemma":[0.9999058,0.0000206417,0.00003237246,0.00001050857,0.00001317994,0.00001738146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004735805,0.00005213081,0.0001559347,0.0001255017,0.00001739439,0.0001373521,0.00001217682,0.0004306924,0.9896899,0.0006347369,0.0003226282,0.007947885],"study_design_scores_gemma":[0.00015955,0.001583938,0.001282451,0.00001775894,0.0000246891,0.0005408137,0.00001179076,0.001431546,0.9797519,0.0001799432,0.01499978,0.00001587548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9491263,0.01314424,0.0192603,0.0004893106,0.0003244928,0.0002221186,0.0008438068,0.0003316529,0.01625772],"genre_scores_gemma":[0.9798889,0.003397766,0.009934846,0.0002712292,0.00005153133,0.0001222094,0.0006666271,0.00004074536,0.005626255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001747312,"threshold_uncertainty_score":0.005845308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005418487397282317,"score_gpt":0.2297840027604592,"score_spread":0.2243655153631769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}