{"id":"W1990800220","doi":"10.1021/cb100161u","title":"<i>N</i><sup>η</sup>-Substituted Arginyl Peptide Inhibitors of Protein Arginine <i>N</i>-Methyltransferases","year":2010,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; University of British Columbia; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Arginine; Peptide; Methylation; Guanidine; Chemistry; Active site; Methyltransferase; Stereochemistry; Moiety; Biochemistry; Binding site; Protein arginine methyltransferase 5; Residue (chemistry); Enzyme; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001866078,0.0002882911,0.0003491691,0.00007732619,0.00004607209,0.000008588933,0.0003163532,0.0007284252,0.00007404118],"category_scores_gemma":[0.0002918359,0.0002711157,0.0001690525,0.0002338438,0.0005184396,0.000007262664,0.000108787,0.0003809678,0.00001645703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000158427,"about_ca_system_score_gemma":0.0001269712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004960688,"about_ca_topic_score_gemma":0.00002306357,"domain_scores_codex":[0.9983241,0.00006139489,0.0004973928,0.0005855187,0.0001254719,0.0004061527],"domain_scores_gemma":[0.9989647,0.00004208114,0.0001437102,0.0005478964,0.0001627585,0.0001388983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000206414,0.00009996519,0.0009754535,0.00002427252,0.00007751468,0.000001089177,0.00002842652,0.00008334791,0.9938321,0.0003218518,0.0007603269,0.003589219],"study_design_scores_gemma":[0.000974165,0.0001663484,0.0001072013,0.00002002708,0.00003111857,0.00002418845,0.00001320182,0.00005606577,0.9613149,0.0002814426,0.03671899,0.000292411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974872,0.0004855353,0.0003338137,0.0003922435,0.0002189034,0.0004135452,0.0000806321,0.00004236122,0.0005457967],"genre_scores_gemma":[0.9964411,0.00007397202,0.001502086,0.0001109867,0.0007394407,0.00007369454,0.0009046252,0.00003691407,0.0001171257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03595866,"threshold_uncertainty_score":0.9999741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005418487397282317,"score_gpt":0.2297840027604592,"score_spread":0.2243655153631769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}