{"id":"W1990803471","doi":"10.1038/gt.2011.59","title":"Molecular adjuvant HMGB1 enhances anti-influenza immunity during DNA vaccination","year":2011,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; INOVIO Pharmaceuticals; Los Alamos National Laboratory; University of Pennsylvania","keywords":"Immunogenicity; Adjuvant; DNA vaccination; Biology; Immune system; Virology; Vaccination; Immunization; Antigen; Hemagglutinin (influenza); Immunity; Immunology; HMGB1; Influenza A virus; Antibody; Virus; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003320411,0.0002085079,0.000337773,0.0001747216,0.0002246194,0.000016149,0.0001929042,0.00007896195,0.0005287789],"category_scores_gemma":[0.00007713568,0.0001695232,0.0001164536,0.000212663,0.00006484825,0.0001353954,0.00008450623,0.0002348241,0.0001380818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008661561,"about_ca_system_score_gemma":0.00007275852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000139482,"about_ca_topic_score_gemma":0.000004456575,"domain_scores_codex":[0.998498,0.0001112345,0.0002788648,0.0002677102,0.0004052092,0.0004389709],"domain_scores_gemma":[0.9990094,0.00002331087,0.00008800551,0.0005143124,0.0002566825,0.0001083107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000680765,0.0001842867,0.007087566,0.00004425079,0.0002617429,0.00006491453,0.002411992,0.000004050376,0.9770516,0.0000555649,0.00003447624,0.01211884],"study_design_scores_gemma":[0.001696493,0.0002321458,0.331217,0.00002117254,0.00001355546,0.00001016753,0.00009670089,0.000007806202,0.6657017,0.0001460516,0.0007372613,0.000119946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865125,0.009097363,0.00007961368,0.00007797679,0.00009687483,0.0005138466,0.000005403992,0.000124183,0.003492203],"genre_scores_gemma":[0.9944445,0.003889557,0.0005930825,0.0007391426,0.000100903,0.0000627445,0.000005707656,0.00003642541,0.0001279243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3241294,"threshold_uncertainty_score":0.6912957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09631824046157805,"score_gpt":0.3628803632345035,"score_spread":0.2665621227729254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}