{"id":"W1990803471","doi":"10.1038/gt.2011.59","title":"Molecular adjuvant HMGB1 enhances anti-influenza immunity during DNA vaccination","year":2011,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; INOVIO Pharmaceuticals; Los Alamos National Laboratory; University of Pennsylvania","keywords":"Immunogenicity; Adjuvant; DNA vaccination; Biology; Immune system; Virology; Vaccination; Immunization; Antigen; Hemagglutinin (influenza); Immunity; Immunology; HMGB1; Influenza A virus; Antibody; Virus; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003907596,0.0002640281,0.0002406124,0.0002425969,0.0001016537,0.0002336797,0.0001755247,0.0003003021,0.001891068],"category_scores_gemma":[0.0002264206,0.0001054548,0.0001884942,0.00009989239,0.0002372681,0.0002229136,0.000191931,0.0005708263,0.000379832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001482823,"about_ca_system_score_gemma":0.0002006019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002255501,"about_ca_topic_score_gemma":0.0003053568,"domain_scores_codex":[0.9998379,0.00006309296,0.000008913044,0.00001689616,0.00002120664,0.00005190108],"domain_scores_gemma":[0.9999005,0.0000351073,0.00001783332,0.00001094814,0.00001219364,0.00002346933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001601063,0.000241501,0.0002317585,0.00006345649,0.00001024678,0.00002251946,0.00002465247,0.000148121,0.9930447,0.0002109061,0.00005852323,0.004342512],"study_design_scores_gemma":[0.0001633082,0.004011477,0.001256663,0.00001115294,0.00003745904,0.00006932759,0.00002874578,0.0005357835,0.9924142,0.00008146754,0.001387535,0.000002861762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952357,0.00153811,0.001714726,0.0001416085,0.00007026532,0.00006042566,0.00007605061,0.0000335215,0.00112963],"genre_scores_gemma":[0.9963393,0.0006267813,0.001145272,0.00006789358,0.00003479989,0.00003464647,0.00009309247,0.000007862002,0.001650329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001891068,"threshold_uncertainty_score":0.006326258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09631824046157805,"score_gpt":0.3628803632345035,"score_spread":0.2665621227729254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}