{"id":"W1990818234","doi":"10.1210/endo.142.2.7930","title":"Parathyroid Hormone-Induced Up-Regulation of Connexin-43 Messenger Ribonucleic Acid (mRNA) Is Mediated by Sequences within Both the Promoter and the 3′Untranslated Region of the mRNA**This work was supported in part by the group Grant GR-13299 from the Medical Research Council. The Natural Science and Engineering Research Council of Canada provided research stipend funding for this work.","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Luciferase; Untranslated region; Messenger RNA; Molecular biology; Biology; Three prime untranslated region; Parathyroid hormone; Forskolin; Promoter; Enhancer; Transcriptional regulation; Gene expression; Transfection; Internal medicine; Gene; Cell culture; Calcium; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001609796,0.0002810345,0.0002987287,0.0002310797,0.0001746459,0.0002478933,0.0001012508,0.0001691668,0.001982335],"category_scores_gemma":[0.000164488,0.0001858442,0.000428721,0.0001575555,0.0003242216,0.0001657891,0.0003171189,0.0004754431,0.000405997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003086528,"about_ca_system_score_gemma":0.0002289686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005359994,"about_ca_topic_score_gemma":0.00116236,"domain_scores_codex":[0.9997937,0.00002075946,0.00001682527,0.0000649868,0.00006570809,0.00003814068],"domain_scores_gemma":[0.9998418,0.0000498771,0.000039502,0.00001633405,0.00001880102,0.00003367677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001854699,0.000004524291,0.00005456107,0.00002038629,0.000001471851,0.00002302095,0.000009085294,0.000008223909,0.999324,0.00002560701,0.00001191817,0.0004987459],"study_design_scores_gemma":[0.00001358978,0.0002617582,0.01658865,0.00001308213,0.00001489244,0.0002825734,0.00003463454,0.0003691171,0.9783431,0.00009411287,0.00397614,0.000008269972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838682,0.005394631,0.00584395,0.0001623898,0.0001187029,0.00009145924,0.0007606554,0.0001643629,0.003595696],"genre_scores_gemma":[0.9849844,0.002521782,0.006262514,0.00008495022,0.00003644066,0.00008392506,0.0009236826,0.00004734622,0.005054967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001982335,"threshold_uncertainty_score":0.006631553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08119768240025264,"score_gpt":0.2997787323452929,"score_spread":0.2185810499450402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}