{"id":"W1990825852","doi":"10.1016/j.neuroscience.2013.12.021","title":"Proliferation, differentiation and amyloid-β production in neural progenitor cells isolated from TgCRND8 mice","year":2013,"lang":"en","type":"article","venue":"Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto; Occupational Cancer Research Centre","funders":"Medical Research Council; Alzheimer Society; Canadian Institutes of Health Research; National Institutes of Health; Krembil Foundation; Wellcome Trust","keywords":"Neurogenesis; Dentate gyrus; Bromodeoxyuridine; Neural stem cell; Progenitor cell; NeuN; Amyloid precursor protein; Genetically modified mouse; Cell biology; Chemistry; Cell growth; Transgene; Alzheimer's disease; Biology; Hippocampus; Stem cell; Biochemistry; Endocrinology; Internal medicine; Immunology; Immunohistochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001411645,0.0003219321,0.0003271121,0.0007055602,0.0001740257,0.0002998115,0.0002355101,0.0002942134,0.001311201],"category_scores_gemma":[0.0001368183,0.0002030038,0.0002706517,0.0003099523,0.0001974859,0.0001811143,0.0001962496,0.001045129,0.0006803118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001565668,"about_ca_system_score_gemma":0.0001385884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007659913,"about_ca_topic_score_gemma":0.0008454734,"domain_scores_codex":[0.9998271,0.000006713426,0.00002500828,0.00006055218,0.00005487431,0.00002580713],"domain_scores_gemma":[0.9998187,0.00003522429,0.00003580466,0.00002218168,0.00002576535,0.00006242323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001375906,0.00003883354,0.0006387076,0.00002262015,0.000004496115,0.00007832923,0.00004558888,0.00002041308,0.997713,0.00003857068,0.00001859993,0.001243183],"study_design_scores_gemma":[0.0000471287,0.0007606387,0.02843505,0.00002179133,0.00004989985,0.0008037046,0.0001362577,0.0007840965,0.965871,0.00009659675,0.002982719,0.00001124576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923548,0.002088844,0.002127875,0.00005171918,0.00005246674,0.00004737567,0.001272507,0.00005454514,0.001949905],"genre_scores_gemma":[0.9734495,0.003101568,0.007768724,0.00008597889,0.00004300796,0.0002441051,0.00427452,0.00008001781,0.01095248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001311201,"threshold_uncertainty_score":0.004386425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02085642724727162,"score_gpt":0.2746796060772913,"score_spread":0.2538231788300197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}