{"id":"W1990850758","doi":"10.1021/ja410513g","title":"Insights into Caerulomycin A Biosynthesis: A Two-Component Monooxygenase CrmH-Catalyzed Oxime Formation","year":2013,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Chemistry; Oxime; Monooxygenase; Hydroxylamine; Flavin group; Biosynthesis; Directed mutagenesis; Stereochemistry; Mutagenesis; Catalysis; Enzyme; Combinatorial chemistry; Biochemistry; Cytochrome P450; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001150135,0.0002459487,0.0001624055,0.0001081933,0.0001116086,0.0002455022,0.0001211,0.0003233286,0.0003370807],"category_scores_gemma":[0.00009825602,0.0000802565,0.0001050466,0.0000783526,0.000180874,0.0003320555,0.0001391821,0.0003632036,0.0001713062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003616317,"about_ca_system_score_gemma":0.0003294789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004470778,"about_ca_topic_score_gemma":0.0005608153,"domain_scores_codex":[0.9999621,0.000006223164,0.000002412271,0.000009627804,0.00001148978,0.000008258439],"domain_scores_gemma":[0.999964,0.000006630124,0.000007436328,0.000004765485,0.000004530079,0.0000126816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005536068,0.00002289212,0.0005269528,0.00003636702,0.000002334217,0.0001583031,0.0000162197,0.0002885966,0.9941365,0.001056745,0.00003543293,0.003664324],"study_design_scores_gemma":[0.00001496505,0.0001666888,0.003603788,0.000007288751,0.00000951396,0.0006448147,0.00004919422,0.004747608,0.9843853,0.001081384,0.005280047,0.000009457025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846468,0.002479216,0.009933229,0.0004972102,0.00002298704,0.00002575219,0.0001278449,0.0000953068,0.002171649],"genre_scores_gemma":[0.9909361,0.001358464,0.006697065,0.00004654346,0.000008158452,0.00000637597,0.000101307,0.000006784934,0.0008391705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004470778,"threshold_uncertainty_score":0.002623856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006061753092984568,"score_gpt":0.2301766570166571,"score_spread":0.2241149039236726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}