{"id":"W1990876051","doi":"10.1016/j.yjmcc.2008.08.012","title":"Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation","year":2008,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Canadian Institutes of Health Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Heart And Stroke Foundation Of Quebec; Rijksuniversiteit Groningen","keywords":"Calpain; Myofibril; Proteases; Troponin I; Internal medicine; Atrial fibrillation; Protein degradation; Troponin complex; Proteasome; Proteolysis; Sarcomere; Actin; Cardiology; Chemistry; Cell biology; Myocyte; Medicine; Biology; Biochemistry; Enzyme; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004970489,0.000114466,0.000277071,0.0001196483,0.00006319241,0.000009536001,0.00003111368,0.0002113512,0.000003515275],"category_scores_gemma":[0.0001752466,0.0001029703,0.000181196,0.00006763234,0.00009796991,0.0000121591,0.000023177,0.0001225298,5.702318e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002080076,"about_ca_system_score_gemma":0.00006419087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001058001,"about_ca_topic_score_gemma":0.00000258747,"domain_scores_codex":[0.9989076,0.0003404509,0.0003208541,0.0001750121,0.0001280432,0.0001280698],"domain_scores_gemma":[0.9995146,0.00003186464,0.0001810076,0.00009259017,0.0001032698,0.00007670857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005254896,0.000006243814,0.04377326,0.00001124185,0.0001386369,0.00007788826,0.00004400624,0.001818369,0.9485022,0.00006292596,0.0002483808,0.004791381],"study_design_scores_gemma":[0.01210747,0.003139824,0.2024477,0.00007316724,0.0005260879,0.004760462,0.0007171817,0.002015879,0.6900238,0.0007768297,0.08238099,0.001030662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751217,0.009735149,0.01442329,0.000142398,0.0003643272,0.0001383721,0.000003017646,0.000003318492,0.00006839135],"genre_scores_gemma":[0.9970975,0.001819584,0.0002068671,0.00003787713,0.0007054074,0.000001535784,0.00005993033,0.00001141133,0.00005989246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2584784,"threshold_uncertainty_score":0.4199007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006192475653748365,"score_gpt":0.2019686003616414,"score_spread":0.195776124707893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}