{"id":"W1990893697","doi":"10.1371/journal.pone.0063313","title":"Sequencing of Candidate Chromosome Instability Genes in Endometrial Cancers Reveals Somatic Mutations in ESCO1, CHTF18, and MRE11A","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre; University of Manitoba","funders":"National Cancer Institute; National Institutes of Health; Avon Foundation for Women; Manitoba Health Research Council; National Human Genome Research Institute; Massachusetts General Hospital; Canadian Institutes of Health Research","keywords":"Biology; Genetics; Sanger sequencing; Microsatellite instability; Somatic cell; Endometrial cancer; Chromosome instability; Cancer research; Mutation; Gene; Chromosome; Cancer; Microsatellite; Allele","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001406054,0.0001780101,0.0001828146,0.0003737844,0.0001487756,0.0001565896,0.00009684343,0.0001798105,0.0004397036],"category_scores_gemma":[0.0005579753,0.00009724533,0.000182065,0.0001971089,0.0001171336,0.00004443933,0.0001229857,0.0001385768,0.00009803769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001581371,"about_ca_system_score_gemma":0.000105541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009429879,"about_ca_topic_score_gemma":0.002110496,"domain_scores_codex":[0.9998759,0.00001721616,0.00001585595,0.00002821449,0.00004332793,0.00001935469],"domain_scores_gemma":[0.9997901,0.00007545479,0.00005419179,0.00002075426,0.00003111902,0.00002835792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002067861,0.00002415057,0.0680401,0.00006375139,0.00005575511,0.001665852,0.0001462491,0.0002056484,0.9222022,0.00004742483,0.00005632472,0.00728575],"study_design_scores_gemma":[0.00003424415,0.0003157107,0.7397287,0.00002827779,0.0001387931,0.01119511,0.0002007993,0.00187249,0.2437058,0.00007103135,0.002697882,0.00001116697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991097,0.0002457918,0.0003696809,0.000009996026,0.000001917091,0.000006727182,0.000118271,0.000004959116,0.0001328832],"genre_scores_gemma":[0.9974533,0.0002991465,0.001349237,0.0000270505,0.000003898495,0.00001273981,0.0004755164,0.000004236324,0.0003748559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009429879,"threshold_uncertainty_score":0.001875043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02217947739427564,"score_gpt":0.2336600326213633,"score_spread":0.2114805552270877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}