{"id":"W1990944630","doi":"10.1038/onc.2011.379","title":"Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation","year":2011,"lang":"en","type":"article","venue":"Oncogene","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":159,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; James S. McDonnell Foundation; National Institutes of Health; Childhood Brain Tumor Foundation; National Brain Tumor Society; Charles H. Revson Foundation","keywords":"Medulloblastoma; Radioresistance; Biology; Cancer research; Genome instability; Protein kinase B; Cell cycle; Mitosis; Sonic hedgehog; PI3K/AKT/mTOR pathway; PTEN; DNA repair; Radiation therapy; DNA damage; Cell biology; Signal transduction; Cell; Genetics; Internal medicine; Cell culture; DNA; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002790635,0.0001953754,0.0002059051,0.00004382453,0.00006912986,0.00001234711,0.0001532687,0.000207726,0.00004690569],"category_scores_gemma":[0.00013563,0.0001918802,0.00005875227,0.00014653,0.0001249471,0.00001098217,0.00007112657,0.0001132139,0.00001976042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005286252,"about_ca_system_score_gemma":0.0001485736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001585418,"about_ca_topic_score_gemma":0.0002139751,"domain_scores_codex":[0.9987178,0.0001118029,0.0002857889,0.0004862238,0.0001131229,0.0002851893],"domain_scores_gemma":[0.99939,0.00002140675,0.0001059625,0.0003388465,0.00005839816,0.0000854032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002228025,0.0001308626,0.008213625,0.00002456974,0.0000294966,0.000005797543,0.0005526249,0.000003852409,0.9891416,0.0000270968,0.00002268599,0.001624951],"study_design_scores_gemma":[0.00081628,0.0003200493,0.01521049,0.00002824784,0.0000132351,0.00001190128,0.0001042607,0.00003304235,0.9791185,0.0002881691,0.003798749,0.0002570342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967743,0.001040777,0.0003950253,0.00004485618,0.00007113814,0.0002670019,0.00002942301,0.00002538611,0.00135212],"genre_scores_gemma":[0.9971128,0.0001722179,0.002196115,0.000124757,0.00009179917,0.00003992474,0.00009755602,0.00002857094,0.0001362847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0100231,"threshold_uncertainty_score":0.7824646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02224131309702791,"score_gpt":0.2334075834858381,"score_spread":0.2111662703888102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}