{"id":"W1990955843","doi":"10.1016/j.molcel.2010.08.015","title":"Elevated Histone Expression Promotes Life Span Extension","year":2010,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":439,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"National Institute of General Medical Sciences; National Cancer Institute; Cancer Center, University of Colorado; National Institutes of Health","keywords":"Biology; Histone; Histone code; Chromatin; Histone methyltransferase; Histone H2A; Histone H1; Cell biology; Chromatin remodeling; Acetylation; Histone H3; Histone-modifying enzymes; Genetics; Nucleosome; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116055,0.0001877474,0.0001329709,0.00003644358,0.00008361585,0.00002838577,0.0002270595,0.0002360549,0.00005995463],"category_scores_gemma":[0.00006931046,0.0001819162,0.00009783862,0.00005990639,0.00005501867,0.000002154672,0.0001648397,0.0001836423,0.00004176675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007428204,"about_ca_system_score_gemma":0.00007053258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001043763,"about_ca_topic_score_gemma":0.00000990544,"domain_scores_codex":[0.9989607,0.00003381199,0.0001943951,0.0004136755,0.0001363687,0.0002610325],"domain_scores_gemma":[0.9990248,0.000003585833,0.00009569438,0.0006289926,0.00008596038,0.0001609718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000192661,0.00009666506,0.0001478269,0.00001717593,0.00000776819,0.00001398735,0.00001878941,0.00005866582,0.9986087,0.00003748307,0.0006987583,0.0002749001],"study_design_scores_gemma":[0.0004129004,0.000117517,0.0004486094,0.000006559136,0.00001309306,0.000009921784,0.00001360373,0.0009497913,0.9841959,0.0001276504,0.01346235,0.0002420913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930906,0.0003027753,0.003845249,0.00009849919,0.0002564971,0.0001863492,0.000007779347,0.00002586519,0.002186384],"genre_scores_gemma":[0.9920229,0.00002839665,0.006466782,0.0003137637,0.00009769153,0.0000128308,0.0002038794,0.00005000391,0.0008038064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0144128,"threshold_uncertainty_score":0.7418329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004004130491097193,"score_gpt":0.2113743994227132,"score_spread":0.207370268931616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}