{"id":"W1990955843","doi":"10.1016/j.molcel.2010.08.015","title":"Elevated Histone Expression Promotes Life Span Extension","year":2010,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":439,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"National Institute of General Medical Sciences; National Cancer Institute; Cancer Center, University of Colorado; National Institutes of Health","keywords":"Biology; Histone; Histone code; Chromatin; Histone methyltransferase; Histone H2A; Histone H1; Cell biology; Chromatin remodeling; Acetylation; Histone H3; Histone-modifying enzymes; Genetics; Nucleosome; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395111,0.0002267937,0.0002522711,0.0002143686,0.0001416134,0.0004717492,0.0001705404,0.0002907728,0.002790621],"category_scores_gemma":[0.000106123,0.0002049956,0.0002494011,0.0001389361,0.000267921,0.0002650566,0.0004547247,0.000886564,0.0005265122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002725945,"about_ca_system_score_gemma":0.0001368792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002107898,"about_ca_topic_score_gemma":0.0004202122,"domain_scores_codex":[0.9998958,0.0000131514,0.000007221286,0.00002985582,0.00001815403,0.0000357492],"domain_scores_gemma":[0.9997655,0.00004165337,0.00003415624,0.0000370875,0.0000144608,0.0001072145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001204313,0.00002180602,0.00009286921,0.000009447163,0.00000246672,0.00002329078,0.000004546575,0.00002046182,0.9990178,0.00009824512,0.00002862935,0.0005600278],"study_design_scores_gemma":[0.00001736331,0.0002195816,0.007443815,0.000003813492,0.000009416349,0.0001116085,0.00002035604,0.0004780375,0.9898984,0.0001230227,0.001670653,0.000003928385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912959,0.001745861,0.003579394,0.0002454199,0.0001035812,0.00001749534,0.0002912313,0.0002218984,0.002499039],"genre_scores_gemma":[0.995023,0.0004458996,0.0008446957,0.00009273677,0.00002720731,0.00001209,0.000300356,0.00003266357,0.003221491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002790621,"threshold_uncertainty_score":0.009335577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004004130491097193,"score_gpt":0.2113743994227132,"score_spread":0.207370268931616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}