{"id":"W1990960245","doi":"10.1016/j.virol.2007.01.011","title":"Immunogenicity of papaya mosaic virus-like particles fused to a hepatitis C virus epitope: Evidence for the critical function of multimerization","year":2007,"lang":"en","type":"article","venue":"Virology","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":139,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hôpital Notre-Dame; Armand Frappier Museum; Institut National de la Recherche Scientifique; Hôpital Saint-Luc; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Immunogenicity; Epitope; Virology; Biology; Capsid; Antigen; Virus; Virus-like particle; Antibody; Immune system; Hepatitis C virus; Recombinant DNA; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002855901,0.0002664055,0.0001320206,0.0001647712,0.0001969721,0.0003242648,0.0001640745,0.0002816071,0.0008626505],"category_scores_gemma":[0.000333997,0.0001165489,0.0002137008,0.00007135447,0.0001955335,0.0002627914,0.0002682653,0.0005581449,0.0003193044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002515943,"about_ca_system_score_gemma":0.0001142262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002548657,"about_ca_topic_score_gemma":0.0001209439,"domain_scores_codex":[0.9998959,0.00002368849,0.000006912294,0.00002309217,0.00002584669,0.00002445716],"domain_scores_gemma":[0.9996182,0.0001122708,0.0000673023,0.00007820423,0.00005433087,0.00006961468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006670571,0.0000140143,0.0002699096,0.000009484315,0.000003002294,0.0000392375,0.00001395196,0.00003055251,0.9988859,0.0001157929,0.00001357633,0.0005379042],"study_design_scores_gemma":[0.00001562662,0.0002318478,0.00589277,0.000002761357,0.00001643021,0.0005480544,0.00002894541,0.001285985,0.990746,0.0002307011,0.0009965646,0.000004333445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965605,0.0002025242,0.002423191,0.00003858032,0.00001279511,0.000006087655,0.00003440737,0.00002384527,0.0006980883],"genre_scores_gemma":[0.9985347,0.00007190501,0.0005314698,0.00003173528,0.000007380866,0.000005802498,0.0001137469,0.00001364341,0.0006896813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008626505,"threshold_uncertainty_score":0.002885878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03211432222148979,"score_gpt":0.3188101761918102,"score_spread":0.2866958539703204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}